This week I learnt about chlorpromazine, which is an antipsychotic. It is also used in short-term management of anxiety, agitation or disturbed behaviour in non-psychotic disorders. Chlorpromazine is an antagonist of many receptors, which include α1 adrenoceptor, M3 muscarinic receptor, H1 Histamine receptor, 5HT2 receptor, dopamine D2 receptor and angiotensin II AT1 receptor. This illustrates one of the pharmacology principles, which is selectivity of a drug. A highly selective drug (‘clean drug’)
There are two categories of antipsychotics that could be used for positive symptoms of schizophrenia that could have helped Nathaniel: atypical or typical antipsychotics. Typical medications are the more current conventional medications used today, while the atypical medications are generally not used unless two other typical antipsychotics have been tried (Pandarakalam, 2016). Some of the overall antipsychotic medication side effects include, dry mouth, constipation, extreme fatigue, weight gain
Meet the Client: Bob Tyler Bob Tyler, a 40-year-old male, is brought to the emergency department by the police after being violent with his father. Bob has multiple past hospitalizations and treatment for schizophrenia. Bob believes that the healthcare providers are FBI agents and his apartment is a site for slave trading. He believes that the FBI has cameras in his apartment to monitor his moves and broadcast them on TV. Initial Assessment The nurse asks Mr. Tyler what he would like to be called
The unlikely route from inflammation to antipsychotics The drug development journey leading to olanzapine (Zyprexa) reaching the market did not always follow the steps of rational drug design. Inspired by the first antipsychotic drugs, it took a while from the first discovery of antipsychotic drugs until Zyprexa was developed. The first antipsychotics were come across largely by chance. They were not specifically tailored to a relevant biological effector as rational drug design promotes. Even
An additional benefit of typical antipsychotics is its efficacy in alleviation of symptoms. Typical antipsychotics due have relative efficacy in reducing many of the hallmark symptoms of psychosis and schizophrenia (Lee, Wu, Habil, Dyachkova & Lee, 2006). Tandon & Wolfgangfleischhacker (2005) report that positive symptoms that typical antipsychotics are at least as effective in reducing compared to the newly reformed atypical antipsychotics include, “delusional thinking, hallucinatory
personality disorder that requires they must take antipsychotic drugs to remain stable. There are different types of antipsychotics like typical and atypical. Typical antipsychotics are classified as the first generation of antipyschotics. The atypical antipsychotics, the second generation, are reported to be safer than the typical antipsychotics because they are the newer form of antipsychotic medication. Even though they are reported to be
Schizophrenia is described by the National Institute of Mental Health as “a chronic, severe, and disabling brain disorder that has affected people throughout history” (n.d.). The most recognizable symptoms of schizophrenia are hallucinations and delusions. Hallucinations involve experiencing sensory stimulation (hearing, seeing, feeling, etc.) when there is no stimulus present. Delusions are false beliefs. Common types of delusions experienced by people with schizophrenia are delusions of persecution
Disorganized schizophrenia, also known as Hebephrenic schizophrenia, is among the subtypes of schizophrenia. It is a chronic and difficult condition that includes disjointed and irrational cognitive behaviors, along with purposeless actions. This type is considered severe because of how it impacts the individual’s abilities to participate in daily activities, including self care. Causes The cause of this condition is not known, but there has been studies of a specific gene referred to as the “schizophrenia
Atypical Antipsychotics are most often used. These second-generation medications are preferred due to the fact that they have a lower risk of serious side effect which can better treat this mental illness. These medications include: Aripiprazole (Abilify), Asenapine (Saphris), Clozapine (Clozaril), Iloperidone (Fanapt), Lurasidone (Latuda), Olanzapine (Zyprexa), Paliperidone (Invega), Quetiapine (Seroquel), Risperidone (Risperdal), and finally Ziprasidone (Geodon). Many of the first-generation antipsychotics
The antipsychotic medications are recommended as pharmacological interventions to treat psychotic episode in psychosis and schizophrenia (NICE 2014). They may be classified as atypical and typical antipsychotics (Meltzer 2013). The atypical drugs refer to as the newer generation of antipsychotics which may have less extrapyramidal side effects (EPS) compared to the typical antipsychotics, also known as the first generation of antipsychotics (Meltzer 2013). Both types of antipsychotic drugs are