Systemic scleroderma

1970 Date of Death: March 30, 2012 Place of Death: Cause of death: Progressive systemic scleroderma 1. Etiology – Progressive systemic scleroderma is a disease in which the immune system begins to attack the body. Suddenly the immune system starts to think that the healthy tissue in the body is harmful and begins to destroy them. There are many different types of this disease and progressive systemic scleroderma affects each person differently. It is considered an autoimmune disorder or disease

Scleroderma, also named Systemic Sclerosis (SSc) is considered a rare systemic connective tissue disease affecting mainly the skin and vascular system in the form of generalized microvascular obliterative lesions affecting mainly the small and medium sized vessels (Black 1995). Current thinking of SSc vascular disease suggests an autoimmune contribution, chemical modifications of the endothelium and a possible viral trigger were proposed (Pandey and Leroy 1998). In SSc, an imbalance in endothelial

Scleroderma is a broad term used to describe a spectrum of disorders identified by skin fibrosis (Succaria, Kurban, Kibbi & Abbas, 2013). It is a serious condition that is classified as either being a systemic or localised autoimmune disease of collagen tissue impacting both internal and external organs (Oksel & Gündüzoğlu, 2014). Due to the vast divergency of this disease there will be brief discussion on the various forms of both systemic and localised scleroderma however, the main focus is to

Systemic sclerosis, also known as, scleroderma or CREST syndrome is a chronic inflammatory, autoimmune connective tissue disease. Scleroderma is a connective tissue disease that involves changes in the skin, blood vessels, muscles, and internal organs. This disease can be classified into two main types, systemic or localized. Systemic scleroderma can affect all parts of the body, such as internal organs, skin, and blood vessels. Localized only affects the skin and is not life threatening, as systemic

Clinical Features: Criteria for Systemic sclerosis 2013 ACR/EULAR Classification Criteria for Scleroderma were developed by the American College of Rheumatology(ACR) and the European League Against Rheumatism(EULAR).Twenty-three candidate items were considered.They were reduced by clustering items and simplifying weights and was then tested by comparing performance in scleroderma patients and control patients, and validated with a group of experts.Skin thickening of the fingers extending proximal

Vasculopathy in Systemic Sclerosis Introduction Systemic sclerosis (SSc) is a multi-faceted, heterogeneous disease of unknown etiology. Despite its high clinical variability, it is consistently characterized by three main elements: vascular alterations, autoimmunity and progressive fibrosis. However, there is increasing evidence that SSc pathogenesis is dominated by vascular changes, as demonstrated by numerous experimental and clinical studies (1). Diagnosis is made by the physician based on the

Low-dose oral imatinib in the treatment of systemic sclerosis interstitial lung disease unresponsive to cyclophosphamide: a phase II pilot study. A clinical trial was performed to verify the effectiveness and tolerability of low-dose imatinibon (Tyrosine kinase inhibitors that may be a therapeutic option for SSc patients) interstitial lung disease in a cohort of SSc patients unresponsive to cyclophosphamide therapy. Due to published clinical trails that were inconclusive about imatinib effectiveness

The emergence of family and systemic therapies in the latter part of the 20th century saw something of a paradigm shift in the world of psychotherapy and counseling. Those in the field during the 1960’s and 1970’s were predominantly occupied with psychodynamic, behavioural and humanistic approaches (Corey, 2009). Theories attached to these forms of therapy emphasized the autonomy of the individual, and the capacity to engage in free, independent choice. In therapeutic settings, much of the discussion

After the breakout of finance crisis, leaders of the G-20 vowed to take control of the derivative market and finally pass the BASEL III. All the participants including the bank， speculators, exchange platform and institutions, regulators, the offices, political leaders and the households who had a harmful effect from the financial crisis require the reassurance for such a crisis to never occur again. Society as a whole suffered a loss from it, because the wide spread fear and constraint of consumption

217). The Dodd-Frank Act utilizes several different measures to determine the level of systemic risk in the financial system. Regulators are encouraged to consider the following criteria when assessing the systemic risk of a firm (pgs. 131-132): 1) The amount and nature of the company’s financial assets. 2) The amount and nature of the company’s liabilities, including the degree of reliance on short-term