Receptor tyrosine kinase

DISSEMINATED GERMINOMAS The Therapeutic Challenge INTRODUCTION The prospect of tumours in the paediatric population is heart wrenching for parents and caregivers alike. The instinctive need for humans to care and protect their offspring leads to emotions of despair, anguish and hopelessness. Neurosurgeons are familiar with these emotions, as brain tumours represent the second most common paediatric tumour(1). Germinomas, even though rare, are unique to the paediatric population and adequate

An antimetabolite, 5FU is a pyrimidine analog that irreversibly inhibits TS. Thymidine is a nucleoside and a major component of the DNA and is hence required by cells for proliferation. Deoxyuridine monophostate (dUMP) upon methylation by TS generates thymidine monophostate (dTMP). 5FU interrupts the activity of TS and creates a shortage in the levels of dTMP. Thus the rapidly proliferating cells undergo death due to lack of thymidine nucleoside. The drug has successful applications in colorectal

mesylate is a protein tyrosine kinase (RTK) inhibitor that exhibits high specificity and potency for ABL, c-kit, and PDGF receptors, which often harbor activating mutations and are typically mutually exclusive of each other and within specific cancer types.2 The compound has been approved as a targeted chemotherapy for Philadelphia chromosome positive chronic and acute myeloid leukemia (Ph+ CML and AML), Ph+ acute lymphoblastic leukemia (ALL), platelet-derived growth factor receptor (PDGFR) aberrancy-related

Methanogens are prokaryotes. A prokaryote cell does not contain a membrane-bound nucleus; they range from 0.1 to 10 µm in total cell size. Methanogens are usually either coccoid (spherical) or bacilli (rod shaped). Each cell is surrounded by a plasma membrane. The cell has no subcellular organelles, only infoldings of the plasma membrane called mesosomes. The deoxyribonucleic acid (DNA) is condensed within the cytosol to form the nucleoid. The cell walls of Methanogens, like other Archaea, lack

Short overview The current technology is based on protein kinase activation by means of stochastic resonance mediated through pulsed electrical fields of very low signal strength. The mode of action reveals how even small pulsed electrical fields can have a major influence on cellular function and physiological consequences. It is well known that biological sensory systems transform analog quantities such us pressure, temperature, electric fields (E-fields) etc. into trains of information. All

Specific aims: EGFR and c-Met are receptor tyrosine kinases (RTKs), and tyrosine kinase inhibitors (TKIs) against these receptors have been initially effective when prescribed to patients in combination with traditional chemotherapy or radiation. However, the overall efficacy of TKIs is limited due to the development of resistance as seen through clinical trials in NSCLC. Epithelial Mesenchymal Transition (EMT) is a process by which epithelial cells undergo phenotypic and morphological changes to

Bromophenols have been identified as potential therapeutics for treating type 2 diabetes mellitus (T2DM) due to their suspected tyrosine phosphatase 1B (PTP1B) inhibitory activity. A new series of bromophenol analogues will be synthesised and their PTP1B inhibitory activity will be tested in in vitro enzymatic assays to elucidate their mechanism of action as PTP1B inhibitors. Background and Introduction Type 2 diabetes mellitus (T2DM) is a metabolic disease that is caused by insulin resistance

c-abl oncogene, which becomes fused to the breakpoint cluster region (bcr) in the Philadelphia chromosome, following translocation. Presence of this bcr-abl gene fusion produces a poorly regulated tyrosine kinase, which results in a much higher level of cell proliferation. The action of this tyrosine kinase results in chronic myelogenous leukemia (CML) symptoms, such as overproduction of white blood cells. 2) Opposed to structural data alone, NMR

silico analysis of single nucleotide polymorphism (SNP) in human FLT3 gene ABSTRACT FLT3 is a member of extracellular receptors on hematopoietic precursors and belongs to the class 3 tyrosine kinase receptor. The FLT3 receptor is receptor gene encodes a 993-amino acid protein. Its location on the chromosome is 13q12. FLT3 receptor ligand , FL-like tyrosine kinase poisoning 3 receptor interaction works to maintain, spread and differentiate from the normal hematopoietic stem. The damaging mutations

Receptor Dimers: Heterodimers and Homodimers. Receptor dimers are receptor complexes formed by two covalently or non-covalently bound receptor subunits. Receptor dimerisation regulates signal transduction in various receptors or alter pharmacology. The Enzyme linked transmembrane receptors (they dimerise only when bound by a ligand to cause activation via autophosphorylation), The G-protein coupled receptors (GPCRs) (they form constitutive dimers to mask the E.R retention motif on the C- terminal)