Ototoxicity

Critique: Transtympanic injections of N-acetylcysteine for the Prevention of Cisplatin-induced Ototoxicity A Feasible Method with Promising Efficacy Riga, M., Chelis, L., Kakolyris, S., Papadopoulos, S., Stathakidou, S., Chamalidou, E., Xenidis, N., Amarantidis, K., Dimopoulos, P., Danielides, V. (2003). Transtympanic injections of N-acetylcysteine for the Prevention of Cisplatin Induced Ototoxicity. A Feasible Method with Promising Efficacy. American Journal of Clinical Oncology, 36(1)

Contextually, development in telehealth have led to the development of the Ototoxicity identification device (OtoID). The device promotes hearing monitoring by a patient during the chemotherapy treatment. Considerably, OtoID is a characterized by patient self-testing and texting of results to the audiology clinic. Conversely, OtoID plays an integral role in monitoring and treatment administration among patients with Ototoxicity. Ototoxicity has become one of the life threatening infection in United States

Outline for Proposal Title: Testing the effect of corticosteroid in reducing sensorineural hearing loss due to platinum-based chemotherapy ototoxicity (include radiation????) Introduction & Theoretical Framework: • The 21st century has seen great progress in diagnosing and treating many types of cancers. Advancements in the medical field are helping more people discover their cancer earlier. Doctors are treating more Stage 1 and Stage 2 cancers than ever before. Survival rates are increasing

1.1 History In 1965 Barnett Rosenberg made the accidental discovery of the biological use cisplatin whilst conducting an experiment on the effects of electrical current on the bacterial E.coli (Escherichia coli). When the electrical current was turned on, it was observed that the cell division was inhibited causing a decline in the density of the bacterium. However, when the electrical field was turned off, the bacterium returned to its normal density. It was later found that the inhibition of cell

containing opioids has increased alarmingly some specialist have termed it as “opioid abuse epidemic”. Zohydro offers a hydrocodone extended release formulation (12 hrs effect) without acetaminophen and its adverse effects as liver toxicity and possible ototoxicity. On the other hand, due to its high hydrocodone dose in just one pill could be very dangerous especially

ALPRAZOLAM Alprazolam is used as an anxiolytic drug and it has nonspecific depressant effects on the central nervous system. It’s used orally. It’s absorbed from gastrointestinal tact greater than 80%. Peak plasma levels usually occur within 2 hours. Alprazolam has a high protein bound (80%). Serum albumin accounts for the majority of the binding. It has a small volume of distribution (less than 1.5L/kg). Alprazolam and its metabolites are excreted primarily in the urine. The mean plasma elimination

Nephrotoxicity is a common and serious complication of aminoglycoside therapy. This complication occurs as a result of acute tubular necrosis. When filtered across the glomerulus, aminoglycosides are partially accumulated in the proximal tubular cells and cause damage. Due to the time period it takes for the medication to accumulate, renal damage may not be apparent for several days even after the medication has been discontinued. Proximal tubules can regenerate, thus when damage occurs renal function

Otic is derived from the Greek word “Otikos” meaning “of or related to the ear”.1 Since the beginning of time, ear problems have always been common, and medications have been given to the ear for local effect.2 The earliest ear preparations were applied by soaking cloth in extracts from plants and then placing it into the ear. 2 Otic preparations are pharmaceutical products for the application on the skin surface surrounding the ear or for instillation into the ear in order to treat conditions of

Assessment: Cystic Fibrosis (CF) is an autosomal recessive genetic disorder most commonly found amongst the Caucasian population. In the United States, the reported prevalence of CF for the Caucasian population is 1:3200, for African American is 1:15000 and for Asian American is 1:310001. The advancements in the treatment of CF have resulted in better quality of life in many CF patients and an increase in life expectancy in many CF patients. Median survival of CF is about 41 years2. In patients

testicular, ovarian, head and neck and non-small cell lung carcinoma and many other types of cancer in the globe 4. CP treatment persuade numerous detrimental side effects including nephrotoxicity cardiotoxicity, myelotoxicity, hepatotoxicity, ototoxicity 5 due to the generation of reactive oxygen species (ROS) like hydroxyl radical and superoxide anion radical (SAR) 6 are