Diamond Coated Machine Tooling Diamond is the hardest material known to man, in this day and age. Typically, diamonds have been known to demonstrate hardness values up to 12000 HV (Vickers Hardness) or approximately 100HRC. Diamond-coated Tungsten Carbide tools have demonstrated improved machining characteristics over coated tool steels commonly used today. With the increased use of composites, ceramics, and other ultra-hard / lightweight materials in numerous industries, diamond-coated machine
Part A : Defects in DNA Replication Cause Cancer I. Introduction As known today, cancer is one of the most lethal diseases in the world. Millions of people died every year caused by various type of cancer, but the concern is that what does really caused the cancer itself? Is it because of the lifestyle people have nowadays? Or because of environment that has changed? Or even sometimes because of the flaw in the replication of DNA? There are lots of probabilities to cause cancer. In this section
Current mechanism and concepts in pathogenesis of Atherosclerosis Introduction Atherosclerosis is classified as a chronic, progressive, and multifactorial disease of moderate and large sized arteries categorised by intimal lesions called atheroma plaques that pushes into the vessel lumens. Atherosclerosis leading to coronary artery is the main cause of coronary artery disease (CAD). It is vital to appreciate the central mechanisms of atherogenesis in order to understand the adverse clinical results
protein they are and how they affect a certain part of the body. They are usually surface receptors that will interact with extracellular matrix. There is a family of alpha and beta classes which would usually form heterodimers. They are used for adhesion purposes most of the time and can also transduce a biochemical signal into or out of the cell. This process is called bidirectional, where the can transmit information from in and out of a cell. There are different structures that integrin’s play
EFFECT OF KAOLIN ON THE MECHANICAL PROPERTIES OF POLYPROPYLENE/ POLYETHYLENE COMPOSITE MATERIAL Samir Nassaf Mustafa ABSTRACT :- In this work, the mechanical and water absorption properties of polymer blend polypropylene (PP) and low density polyethylene (LDPE) at constant ratio (50/50) composites as a function of kaolin powder weight content in the grain size (100,120 µm) were investigated. Polymer composite was fabricated by mixing polymer blend ( PPLDPE) with (0, 1, 3 ,5, 10, 14) wt.% of kaolin
et al., 2012). These results confirmed hypothesis that Runx2 is a bi-functional regulator, activating or repressing transcription (van der Deen et al., 2012). An interesting result of this study involved Runx2’s influence on genes involving cell adhesion and motility (van der Deen et al., 2012). Combining data from the immunprecipation and gene expression profiles with siRNA, researchers concluded target genes can be both up-regulated and down-regulated with Runx2 depletion (van der Deen et al.,
Ovarian Cancer: Development, symptoms, diagnosis and treatment. Ovarian cancer is the rapid and unregulated division of the ovarian cells and is referred to as the ‘most lethal gynaecologic cancer’ (1). Despite a small lifelong risk of only 1.3% in the general population and only a small proportion of 1.3% of all new cancers, ovarian cancer is the fifth-leading cause of cancer-related death in women (2). This essay will give an insight into the development of this type of cancer, the symptoms, diagnosis
(parent) vessel walls. The endothelial cells then proliferate into the surrounding matrix and form solid sprouts connecting neighbouring vessels. As sprouts extend toward the source of the angiogenic stimulus, endothelial cells migrate in tandem, using adhesion molecules called integrins. These sprouts then form loops to become a full-fledged vessel lumen as cells migrate to the site of angiogenesis. Sprouting occurs at a rate of several millimeters per day, and enables new vessels to grow across gaps in
In 1981 Weissbluth et al. reported the first case of extensive MS associated with GM1 ganglio sidosis 9. Since then some other cases have been reported linking other IEM with MS and GM1 gangliosidosis. There are 54 reported cases of extensive MS with various IEM, in which 25 cases are associated with Hurler syndrome, 17 with GM1G, 9 in Hunter syndrome, 2 in ᶐ-mannosidosis, and 1 with Niemann-Pick disease6. Of these 25 cases of Hurler syndrome, 19 have been reported in a single study by Gonzalez
A 67-year-old male presents to the emergency department with a 2-day history of fever and productive cough. He feels very unwell. The patient is known to have multiple myeloma, a diagnosis established 1 year ago. He was induced with high-dose chemotherapy and maintained on bortezomib. Vital signs: Temperature 38.8ºC (101.8°F), blood pressure 125/88 mmHg, heart rate 98 beats/min, respiratory rate 20 breaths/min. Crepitations are heard in the right middle chest. Chest x-ray shows areas of consolidation