Chapter 5.2, Problem 8ATS

The quantitative differences in biological activity between the two enantiomers of a compound are sometimes quite large. For example, the D isomer of the drug isoproterenol, used to treat mild asthma, is 50 to 80times more effective as a bronchodilator than the L isomer. Identify the chiral center in isoproterenol. Why do the two enantiomers have such radically different bioactivity?

Which of the following statement is NOT correct? 2 3 4 a. b. C. d. a b C d Constitutional isomers are compounds whose atoms are connected differently. Stereoisomers are compounds whose atoms are connected in the same order but with a different spatial arrangement. Diastereomers are stereoisomers that are mirror images. Molecules that are not identical to their mirror images are a kind of stereoisomers called enantiomers.

Ealg äbäi Give a common name for each compound (c) CICH2CH20CH3 إجابتك نقطة واحدة Give a common name for each compound (a) OCH3 إجابتك نقطة واحدة Give a common name for each compound OCH,CH3 (d) إجابتك 6 o 2 änio التالي رجوع >

Following is a structural formula for cortisol (hydrocortisone). Draw a stereo- representation of this molecule showing the conformations of the five- and six-membered rings. CH,OH C=0 CH OH HO H3C H Cortisol (Hydrocortisone)

PGF 2a is a prostaglandin, a group of compounds that are responsible for inflammation (Section 19.6). (a) How many tetrahedral stereogenic centers does PGF 2a contain? (b) How many double bonds can exist as cis and trans isomers? (c) Considering both double bonds and tetrahedral stereogenic centers, what is the maximum number of stereoisomers that can exist for PGF20? OH HO -CH₂CH=CH(CH₂)3COOH CH=CHCH(OH)(CH₂)4CH3 PGF₂α

Propylamine (bp 48°C), ethylmethylamine (bp 37°C), and trimethylamine (bp 3°C) are constitutional isomers with the molecular formula C3H9N. Account for the fact that trimethylamine has the lowest boiling point of the three and propylamine has the highest.

Draw the structure of 2-azacyclopentanone, g-butyrolactam:

Assign an IUPAC name for the following compound: Configuration of chiral centers: O 1-methylcyclohexanol O2-methylcyclohexanol O 1.2-methylcyclohexanol • 1-methylcyclohexol OH

Consider the chiral drug compound 1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol: بطنطا 2 3 OH One of the carbons is chiral. Which one (enter a number)?