Chapter 5, Problem 84CP

What is the product of the following multistep synthesis reaction sequence? (1) Ch (2) xs NaNH2 (3) methyliodide (4) O3, ozonolysis CO2 ОН OH

In the conversion of acetone to aceto-cyanohydrin, the effect of electron-donating substituents on the tetrahedral intermediate is to: stabilize the charge on oxygen destabilize the carbocation formed destabilize the ch charge on oxygen make the intermediate more crowded Which of the following is not indicated by this reaction? KI, H;PO4 ether, 25° C The reaction occurs in solution. It occurs at room conditions. The reaction is carried out with an acid catalyst. The solvent is KI. Predict the increasing rate of reaction of the following alkenes with HCI. 1. 2-butene II. 2-methyl-2-butene II. ethene (A I, II, II B II, I, II II, III, I III, I, II

The rate constant for the uncatalyzed reaction of two molecules of glycine ethyl ester to form glycylglycine ethyl ester is 0.6 M-1s-1. In the presence of Co2+, the rate constant is 1.5 x 106 M-1s-1. What rate enhancement does the catalyst provide?

The following bicyclic ketone has two a-carbons and three a-hydrogens. When this molecule is treated with D,O in the presence of an acid catalyst, only two of the three a-hydrogens exchange with deuterium. The a-hydrogen at the bridgehead does not exchange. H these two a-hydrogens exchange H. this a-hydrogen does not exchange H How do you account for the fact that two a-hydrogens do exchange but the third does not? You will find it helpful to build models of the enols by which exchange of a-hydrogens occurs.

chlorocyopentane may be synthesised in two different ways. fill in the missing reactant required for each pathway

Write the mechanism for CO2 reaction of ethyl acetoacetate (CH3COCH₂CO₂Et) with 1) NaOEt; 2) isobutyl bromide; 3) NaOH; 4) H3O*; and 5) heat. Write structures for each intermediate and show mechanism arrows.

Which one below better describes the synthesis of steroids? Steroids synthesis depends on a cascade of carbocations and hydride and methyl shifts on a diterpene Steroids synthesis depends on the reaction of terpenes making cyclohexanes Steroids synthesis depends on epoxidation of C-2 of a triterpene that triggers carbocation rearrangements and elimination Steroids synthesis depends on conversion of a triterpene -squalene into 4 cyclohexanes fused rings

2305032118517 CHO H-C-OH H-C-OH H₂C₂OH CHO Ho-C-tt A D-aldotetrose yields a mixture of the two compounds shown below when subjected to Kiliani - Fischer Chain extension synthesis. What is the Structure of the aldotetrose? 3 CH₂OH Compound I H-C-OH CHO HO-C-H Ho C-H сно HO-C-H WOO Н-С-он H-C-OH CH ₂ OH Compound II CHO H² C-OH HO-C-H CH₂OH CH ₂ OH CH₂OH CA) (B) (D) (E) Both choices (B) and (C) could be the correct structure of D-erythrose. CHO H₂C-OH HC OH CH ₂ OH ctrl MAND option

3 Two equilibrium reactions are given: In the first, acetaldehyde forms with methanol hemiacetal. In the second, D‐glucose forms the hemiacetal form. Formulate them both equilibria. While in the first case the thermodyn. balance on the acetaldehyde side, the hemiacetal form clearly dominates in the second case. Give reasons for these differences and explain.