Principles of Biology
Principles of Biology
2nd Edition
ISBN: 9781259875120
Author: Robert Brooker, Eric P. Widmaier Dr., Linda Graham Dr. Ph.D., Peter Stiling Dr. Ph.D.
Publisher: McGraw-Hill Education
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Chapter 36, Problem 2CCQ
Summary Introduction

To analyze:

The advantage of CO2, H+, and heat as major factors for decreasing the affinity of hemoglobin for oxygen.

Introduction:

The gaseous exchange takes place in the respiratory system. The air inspired is transported to the alveoli in the lungs, where the exchange of gases takes place. The exchange of gases depends on the partial pressure of the gases. The oxygen from the alveoli (partial pressure of oxygen is more than blood) reversible bind to the Hb (hemoglobin) in the blood and produces compound oxyhemoglobin.

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Illustrate how the PaO2 and SaO2 can be very misleading and dangerous when the hemoglobin level is not entered into the patient’s oxygen transport calculations?
o Suppose Gina climbs a high mountain where the oxygen partial pressure in the air decreases to 70 torr. Assume that the pH of her tissues and lungs is 7.4 and the oxygen concentration in her tissues is 20 torr. The P50 of hemoglobin is 26 torr. The degree of cooperativity of hemoglobin (n) is 2.8. Estimate the percentage of the oxygen-carrying capacity that she utilizes. oxygen-carrying capacity utilized: After Gina spends a day at the mountaintop, where the oxygen partial pressure is 70 torr, the concentration of 2,3-bisphosphoglycerate (2,3-BPG) in her red blood cells increases. Why does increasing the concentration of 2,3-BPG in Gina's blood cells help her function well at high altitudes? The P50 value of her hemoglobin increases, promoting oxygen delivery to tissues. The P50 value of her hemoglobin decreases, causing more blood-to-tissue oxygen offloading. The extra 2,3-BPG stabilizes the relaxed, or R, state of hemoglobin, increasing oxygen binding. Excess 2,3-BPG binds oxygen…
Explain the three factors that affect the affinity of hemoglobin to oxygen
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