Pyrrole undergoes electrophilic aromatic substitution preferentially at the 2 position as illustrated by the synthesis of 2-nitropyrrole. CH,COOH + HNO3 + H,O `NO2 5°C H Рyrrole 2-Nitropyrrole Write resonance contributing structures for the intermediate formed by attack of NO,+ at the 2 and 3 positions of pyrrole. From examination of these intermediates, offer an explanation for preferential nitration at the 2 position.

A common illicit synthesis of methamphetamine involves an interesting variation of the Birch reduction. A solution of ephedrine in alcohol is added to liquid ammonia, followed by several pieces of lithium metal. The Birch reduction usually reduces the aromatic ring, but in this case it eliminates the hydroxy group of ephedrine to give methamphetamine. Propose a mechanism, similar to that for the Birch reduction, to explain this unusual course of the reaction.

In the reaction between 3-pentanone and 1-propanol in the presence of acid catalyst, the resulting FINAL acetal product has bonded to the four different sides of the central carbon. (NOTE: The numbers in the responses should be subscripted.) -СН2CH3, -СН2CНЗ, -ОСН2СНЗ, and -OCH2CНЗ -(CH2)4CH3, -(CH2)4CH3, -OCH2CH2CH3, and -OCH2CH2CH3 О -н, -СН2СHЗ, -ОСН2СH2CНЗ, and -OCH2CH2CH3 -CН2CH3, -СH2СНЗ, -ОСН2СH2CH3, and -OСH2СH2CH3 -CH2CH3, -CH2CH3, -OCH2CH2CH3, and -OH

Chemistry Please help explain this textbook question: Although N, N -dimethylaniline is extremely reactive toward electrophilic aromatic substitution and is readily substituted by weak electrophiles, such as diazonium and nitronium ions, this reactivity is greatly diminished by the introduction of an alkyl substituent in an ortho position.

Give the structure of the organic product formed after the following series of reactions. Br Gee die struktuur van die organiese produk wat gevorm word na die volgende reeks van reaksies. 1) Mg 2) 4-methylpentanal | 4-metielpentanaal 3) PBr3 4) propylamine | propielamien 5) NaHCO3

Enamines can serve as enolate surrogates in reactions at the a-carbon. In the reaction sequence, the structures of the enamine addition product – the initial zwitterion and its neutral tautomer – are shown. Draw the structures of the two reactants forming these intermediates, and draw the structure of the final product, obtained via hydrolysis of the neutral intermediate. initial zwitterionic intermediate neutral intermediate tautomerization Reactants H,0 hydrolysis product Draw the two reactants. Draw the hydrolysis product. Select Draw Rings More Erase Select Draw Rings More Erase H H

Suggest a strategy for converting 1-methylcyclohexene into 1-cyclohexylmethanol. Provide the structures for the major organic products frormed in each step.

Propose a synthesis for the following compounds. As starting materials, you may use cyclopentanol, alcohols containing no more than four carbon atoms, and any reagents and solvents. Trans-cyclopentane-1,2-diol.