Genetics: Analysis and Principles
5th Edition
ISBN: 9780073525341
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 21.5, Problem 1COMQ
A means of introducing a cloned gene into cells for gene therapy is via
a. liposomes.
b. retroviral vectors.
c. T-DNA vectors.
d. both a and b.
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Which of the following is a concern of in-vivo gene therapy?
A. Lytic vector expression
B. Integration into target region
C. Immune response to viral vector
D. Production of chimera
Which of the following best describes the approach that wasused in the first gene therapy trial for treating SCID?a. The normal ADA gene was introduced by injecting liposomesdirectly into the patients’ bodies. b. Lymphocytes were removed from a SCID patient, the normalADA gene was transferred into the lymphocytes vialiposomes,and then the lymphocytes were returned to thepatient’s body.c. Lymphocytes were removed from a SCID patient, the normalADA gene was transferred into the lymphocytes via a retrovirus,and then the lymphocytes were returned to thepatient’s body.d. None of the above describe the approach used in the trial.
. a. Compare the means by which retroviral and AAVvectors deliver therapeutic genes to human cells.b. Explain the advantages and disadvantages of eachof the two viral vectors.
Chapter 21 Solutions
Genetics: Analysis and Principles
Ch. 21.1 - 1. Which of the following uses of microorganisms...Ch. 21.1 - Prob. 2COMQCh. 21.1 - Prob. 3COMQCh. 21.2 - When a cloned gene is inserted into a noncritical...Ch. 21.2 - Prob. 2COMQCh. 21.2 - Prob. 3COMQCh. 21.3 - Prob. 1COMQCh. 21.3 - Prob. 2COMQCh. 21.4 - Prob. 1COMQCh. 21.4 - Prob. 2COMQ
Ch. 21.5 - A means of introducing a cloned gene into cells...Ch. 21.5 - 2. Which of the following best describes the...Ch. 21 - 1. What is a recombinant microorganism? Discuss...Ch. 21 - Prob. 2CONQCh. 21 - 3. What is bioremediation? What is the difference...Ch. 21 - Prob. 4CONQCh. 21 - Prob. 5CONQCh. 21 - Prob. 6CONQCh. 21 - 7. What is a transgenic organism? Describe three...Ch. 21 - Prob. 8CONQCh. 21 - Explain the difference between gene modification...Ch. 21 - As described inChapter 5, not all inherited traits...Ch. 21 - Prob. 11CONQCh. 21 - 12. Discuss the concerns that some people have...Ch. 21 - Prob. 1EQCh. 21 - 2. Bacillus thuringiensis makes toxins that kill...Ch. 21 - Prob. 3EQCh. 21 - Prob. 5EQCh. 21 - Prob. 6EQCh. 21 - What is a gene knockout? Is an animal or plant...Ch. 21 - Prob. 8EQCh. 21 - Evidence [see P. G. Shiels, A. J. Kind, K. H....Ch. 21 - Prob. 13EQCh. 21 - 10. What is reproductive cloning? Are identical...Ch. 21 - Researchers have identified a gene in humans that...Ch. 21 - Treatment of adenosine deaminase (ADA) deficiency...Ch. 21 - Several research studies are under way that...Ch. 21 - Prob. 4EQCh. 21 - Prob. 9EQCh. 21 - Prob. 10EQCh. 21 - E12. When transgenic organisms are made, the...Ch. 21 - Prob. 1QSDCCh. 21 - 2. A commercially available strain of P....Ch. 21 - Prob. 3QSDC
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- D) RNA polymerase 29. In lecture, we discussed some of the new platforms for COVID-19 vaccines. Adenovirus-vector vaccines and mRNA vaccines both involve the introduction of pieces of DNA or RNA, respectively. In both cases, the objective is to ... A) enable the human body to produce the SARS-coV-2 genome. B) enable the human body to produce the SARS-coV-2 spike protein. C) inhibit viral polymerase. D) inhibit neuraminidase. E) inhibit reverse transcriptase.arrow_forwardImmunofluorescence and GPF tagging are most commonly used to... a. localize proteins within a cell or organism. b. localize mRNA inside a cell or organism. c. deduce the function of specific genes within an organism. d. follow a signal transduction pathway within a cell or organism.arrow_forwardWhich of the following best describes the mechanism of action of the antibiotic streptomycin? A. it disrupts protein synthesis in resistant bacteria. B. Streptomycin inhibits cell wall synthesis in all bacterial species. C. Streptomycin creates mutations in bacteria which cause them to become resistant. D. It disrupts protein synthesis in nonresistant bacteria.arrow_forward
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