Chapter 21.2, Problem 2P

Label the alkene in each drug as E or Z. Enclomiphene is one component of the fertility drug Clomid. Tamoxifen is an anticancer drug. Clavulanic acid is sold in combination with the antibiotic amoxicillin under the trade name Augmentin.

Match each reagent to the product that it forms. Multiple reagents may form the same product. нох Reagent Reagents SOCI2, pyridine: C CISO2CH3, pyridine: E HCI: A PCI 3: A A) B) "It "ft "bl H₂O D) E) F) پہلے علی علیہ

Draw the tautomer of this enol. Include all lone pairs. Ignore inorganic byproducts. :OH: :0: H3O+ Draw Tautomer

Draw the enol or keto tautomer(s) of each compound.

Draw the enol form of each keto tautomer in parts (a) and (b), and the keto form of each enol tautomer in parts (c) and (d).

When a carbonyl compound is attacked by a nucleophile resulting in the formation of a new stereogenic center, what product(s) will be formed? A) A racemic mixture of the two possible enantiomers B) Contains more of one enantiomer than another because of steric reasons around the carbonyl C) Contains more of one enantiomer than another depending on the temperature of the reaction D) Contains different products depending on the solvent used

Draw the major product formed when HBrHBr reacts with the epoxide. Use wedge–dash bonds, including hydrogen atoms at each stereogenic center, to show the stereochemistry of the product.

Answer the following questions about curcumin, a yellow pigment isolated from turmeric, a tropical perennial in the ginger family and a principal ingredient in curry powder.a.In Chapter 11, we learned that most enols, compounds that contain a hydroxy group bonded to a C=C, are unstable and tautomerize to carbonyl groups. Draw the keto form of the enol of curcumin, and explain why the enol is more stable than many other enols. b.Explain why the enol O—H proton is more acidic than an alcohol O—H proton. c. Why is curcumin colored? d.Explain why curcumin is an antioxidant.

Draw the structure for the transition state in each reaction.