EBK ORGANIC CHEMISTRY-PRINT COMPANION (
4th Edition
ISBN: 9781119776741
Author: Klein
Publisher: WILEY CONS
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Based on this retrosynthetic analysis, propose a synthesis of the anticoagulant
(a substance that inhibits blood clotting) diphenadione.
OEt
OEt
Diphenadione
Diethyl phthalate
Because of its anticoagulant activity for blood, this compound is used as a rodenticide.
Nicotinic acid, more commonly named niacin, is one of the B vitamins. Show how nico-
tinic acid can be converted to (a) ethyl nicotinate and then to (b) nicotinamide.
COH
COET
CNH,
Nicotinic acid
Ethyl nicotinate
Nicotinamide
(Niacin)
Following are two possible retrosynthetic analyses for the anticholinergic drug cycri-
mine. Fill in the details of each potential synthesis.
O:
OH
+
H.
Cycrimine
(гасemic)
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