Genetics: Analysis and Principles
5th Edition
ISBN: 9780073525341
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 16.2, Problem 1COMQ
For the Igf2 gene, where do de novo methylation and maintenance methylation occur?
a. De novo methylation occurs in sperm, and maintenance methylation occurs in egg cells.
b. De novo methylation occurs in egg cells, and maintenance methylation occurs in sperm cells.
c. De novo methylation occurs in sperm, and maintenance methylation occurs in somatic cells of offspring.
d. De novo methylation occurs in egg cells, and maintenance methylation occurs in somatic cells of offspring.
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Explain how DNA methylation could be used to regulate gene expression in a tissue-specific way. When and where would de novo methylation occur, and when would demethylation occur? What would occur in the cells that give rise to eggs and sperm?
Imagine a scenario in which prenatal testing of a human female fetus indicates that the baby will have a normal XX karyotype but is heterozygous for a mutation that inactivates the Xist promoter. Allele “Xr” represents the mutated version of the Xist promoter, and “XR” represents the normal version of the Xist promoter.
How will this mutation affect the process of X inactivation?A. "X inactivation will still be random with both mutant and normal X chromosomes being randomly inactivated"
B. "The chromosome with the mutant Xist promoter will always be active"
C. "The chromosome with the mutant Xist promoter will always be inactivated"
D. "The normal X chromosome (no mutation in Xist) will always be active"
E. "The normal X chromosome (no mutation in Xist) will always be inactivated"
How is the expression of genes controlled at the chromosomal level?
A.
DNA can synthesize extra histones as needed
B.
DNA can either be condensed into heterochromatin or decondensed into euchromatin
C.
DNA can be unwound into euchromatin to reduce the level of expression
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The expression of DNA can only be controlled at the transcriptional level
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DNA is spontaneously deleted from a chromosome if not needed
Chapter 16 Solutions
Genetics: Analysis and Principles
Ch. 16.1 - Which of the following are examples of molecular...Ch. 16.1 - 2. An epigenetic modification to a specific gene...Ch. 16.1 - Prob. 3COMQCh. 16.1 - Epigenetic changes may a. be programmed during...Ch. 16.2 - 1. For the Igf2 gene, where do de novo methylation...Ch. 16.2 - 2. For XCI to occur, where are the Xist and Tsix...Ch. 16.2 - 3. Which of the following possibilities could...Ch. 16.3 - 1. When mice carrying theallele exhibit a darker...Ch. 16.3 - Which of the following types of epigenetic changes...Ch. 16.4 - Prob. 1COMQ
Ch. 16.4 - Prob. 2COMQCh. 16.4 - Prob. 3COMQCh. 16.4 - Prob. 4COMQCh. 16 - Prob. 1CONQCh. 16 - List and briefly describe five types of molecular...Ch. 16 - Prob. 3CONQCh. 16 - What is the key difference between cis and...Ch. 16 - Prob. 6CONQCh. 16 - Prob. 7CONQCh. 16 - 7. Outline the molecular steps in the process of...Ch. 16 - Prob. 9CONQCh. 16 - 9. In general, explain how epigenetic...Ch. 16 - 10. What are the contrasting roles of trithorax...Ch. 16 - Describe the molecular steps by which polycomb...Ch. 16 - Prob. 13CONQCh. 16 - Using coat color in mice and the development of...Ch. 16 - How can environmental agents that do not cause...Ch. 16 - Prob. 5CONQCh. 16 - Define alternative splicing. What are advantages...Ch. 16 - What is the function of a splicing factor? Explain...Ch. 16 - Figure 16.8 shows the products of alternative...Ch. 16 - Lets suppose a person is homozygous for a mutation...Ch. 16 - Prob. 20CONQCh. 16 - What are the advantages and disadvantages of mRNAs...Ch. 16 - Prob. 22CONQCh. 16 - Prob. 23CONQCh. 16 - Prob. 24CONQCh. 16 - Describe how the binding of the iron regulatory...Ch. 16 - Prob. 1EQCh. 16 - In the experiments described in Figure 16.8,...Ch. 16 - Prob. 3EQCh. 16 - A research study indicated that an agent in...Ch. 16 - Lets suppose you were interested in developing...Ch. 16 - E6. In Experiment 16A by Fire and Mello, were they...Ch. 16 - E7. Explain how the data of Fire and Mello...Ch. 16 - Prob. 8EQCh. 16 - 2. Discuss the similarities and differences of...Ch. 16 - How are regulatory transcription factors...
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