Chapter 13, Problem 2CTQ

Write the reagents and reaction conditions that are necessary for each of the following transformations.

Define nucleophilic aromatic substitution ?

Draw the two reactants used to form the following compound, label the nucleophile and the electrophile, and using arrows show the points of attack of the nucleophile on the electrophile that enables the formation of the heterocyclic product.

Define Electrophilic Aromatic Substitution ?

Draw eugenol as a line structure. The double bonds of the benzene ring are fairly unreactive unless you use special catalysts. But the double bond on the side group is reactive. Draw the mechanism of eugenol reacting with HBr to form the two possible carbocation intermediates. Put your intermediates into square brackets. Label each carbocation as a methyl carbon or 1°, 2°, or 3°. Then circle a more stable carbocation if one is more stable. Can you guess what the final product is?

Define Nucleophilicity Versus Basicity ?

) Label each of the following using N for nucleophile and E for electrophile. OH ČI H+ Он „NH2 BH3 H2O B

Consider the following nucleophilic substitution reaction. The compound listed above the arrow is the solvent for the reaction. If nothing is listed over the arrow, then the nucleophile is also the solvent for the reaction. I acetone + HS

Draw the products of homolysis or heterolysis of each attached indicated bond. Use electronegativity differences to decide on the location of charges in the heterolysis reaction. Classify each carbon reactive intermediate as aradical, carbocation, or carbanion.