EBK ORGANIC CHEMISTRY-PRINT COMPANION (
4th Edition
ISBN: 9781119776741
Author: Klein
Publisher: WILEY CONS
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Compounds with polyfunctional groups must follow priority rule. Which of the following compound is correctly named. Justify your claim and construct its correct structure.
Compound A: 3-amino-7-carboxy-4-oxoheptanamide
Compound B: 3-amino-7-carbamoyl-4-oxoheptanoic acid
Compound C: 3-amino-4-ox0-7-carbamoylheptanoic acid
Compound D: 3-amino-4-oxo-7-carboxyheptanamide
There are 20 common, naturally occurring amino acids from which all proteins are derived (as will be discussed in Chapter 25),
although many other less common amino acids have been isolated from natural sources. Valine is one of the 20 common amino acids,
and it was used as a starting material in the laboratory synthesis of an uncommon amino acid (Tetrahedron 1997, 53, 1151-1156).
During one of the steps in the synthesis, compound 1 was treated with HBr under conditions that favor radical addition, giving
stereoisomers 2 and 3. Draw the structures of 2 and 3, and describe their stereoisomeric relationship.
H.
LOCH3
HBr
2 + 3
hv
H
(S)-valine
Modify the given copies of compound 1 to drawthe structures of 2 and 3. You can use the single bond tool to add/remove double
bonds.
CH2
CH2
H,C-
H3C-
-CH,
-CH,
Edit Drawing
Describe the relationship of 2 and 3.
O They are enantiomers.
O They are superimposable.
They are diastereomers.
O They are constitutional isomers.
1. Biogenic Amines are inactivated primarily by
a. Sulfonation
b. Glucoronidation
c. Aromatic hydroxylation
d. Methylation
2. A drug can exert its pharmacological effect only if it is
a. Protein bound
b. Protein unbound
c. Free drug
d. Both B & C
e. Both A & C
3. In order for the drug to be ready and available for absorption, it must be release first from its dosage form with the exception of:
a. Capsule
b. Tablet
c. Solution
d. Suspension
4. All of the following are true, except
a. Solubility increase with decrease particle size
b. Solubility increase with increase surface area
c. Solubility increase with increase particle size
d. Solubility decrease with decrease surface area
5. The rate in which the drug appears in the bloodstream is also known as
a. Half-life
b. Potency
c. Bioavailability
d. Area under the curve
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