Barbiturates are prepared by treating a derivative of diethyl malonate with urea in the presence of sodium ethoxide as a catalyst. Following is an equation for the preparation of barbital, a long-duration hypnotic and sedative, from diethyl diethylmalonate and urea. -OEt H,N -NH 1. EtO-Na+ + 2 ELOH 2. Н,О -OEt H,N -NH Diethyl diethylmalonate Urea 5,5-Diethylbarbituric acid (Barbital) Barbital is prescribed under one of a dozen or more trade names.

Barbiturates are prepared by treating a derivative of diethyl malonate with urea in the presence of sodium ethoxide as a catalyst. Following is an equation for the preparation of barbital, a long-duration hypnotic and sedative, from diethyl diethylmalonate and urea. -OEt H,N -NH 1. EtO-Na+ + 2 ELOH 2. Н,О -OEt H,N -NH Diethyl diethylmalonate Urea 5,5-Diethylbarbituric acid (Barbital) Barbital is prescribed under one of a dozen or more trade names.

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter19: Carboxylic Anhydrides, Esters, And Amides

Section: Chapter Questions

Problem 19.45P

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