Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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You discover a mutant mouse whose skeletal muscles do not work properly. You remove a piece of muscle tissue in an attempt to discover the problem. The only abnormal thing you can find is that the acetylcholinesterase gene seems to be OVER-expressed, resulting in excess amount of this enzyme in and around the NMJ. How does this affect contraction?
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- How do the regulatory proteins work to regulate contraction?arrow_forwardCompare the rate of Ca2+ release from the sarcoplasmic reticulum to the rate of Ca2+ return back to the sarcoplasmic reticulum. Which of the following is true? The rate of ca2+ returns is faster than the rate of ca2+ release The rate of ca2+ release is faster than the rate of ca2+ return Rates of Ca2+ release from and return to the sarcoplasmic reticulum are the same.arrow_forwardYou are helping Eldon Tyrell create replicants to work in off-world colonies. You want to design muscle cells that can produce the most tension. These muscle cells will have an abundant amount of: Moments that will be lost in time, like tears in rain... Sarcolemma Mitochondria O Myofibrilarrow_forward
- Can you modify this experiment so that the mass lifted by the muscle contraction continues to increase for every trial? If yes, explain how it should be modified. If no, explain why.arrow_forwardYou are studying a Drosophila protein called FROZN that you think is a vesicle snare that plays a role in exocytosis of synaptic vesicles containing acetylcholine at the neuro-muscular junction. Because this protein has been isolated from neuromuscular junctions, you hypothesize that this snare is a Ca+2 sensor that mediates the final merging of vesicles with the membrane. To test this hypothesis you perform 2 experiments: 1. You make a mutant Drosophila that lacks FROZN and find that synaptic vesicle release at the neuromuscular junction is blocked. 2. You block Ca+2 entry into the presynaptic neuron terminal in a normal (wild type) fly and find that synaptic vesicle release is blocked. Do these experiments support your hypothesis that FROZN is a vesicle snare and is the Ca+2 sensor? Is there another possible explanation for the function of FROZN? Explain your answer.arrow_forwardThe sliding filament model depicts how myosin motors attached to actin lead to muscle contraction. This process proceeds in a precise series of events. Indicate which of the following shows the correct order of steps in the sliding filament model. Group of answer choices Myosin binds ATP; myosin tightly binds actin; power stroke; myosin releases actin Myosin binds GTP; myosin releases actin; power stroke; myosin tightly binds actin Actin binds ATP; power stroke; myosin tightly binds actin; actin releases ADP Actin binds ADP; myosin releases actin; power stroke; actin releases ADParrow_forward
- Describe the position where wrist and finger are in full extension. What sensation will be felt in this position? What explains this sensation that you felt when the wrist and fingers were positioned in extension? *NOTE: Apply any of the following concepts to the explanation as deemed appropriate and connected to the situation above: Mucle Contraction, Concentric Contraction, Isometric Contraction, Eccentric Contraction, Force Velocity Curve, Stretch Reflex, Reciprocal Inhibition, Autogenic Inhibition, Length-Tension Relationshiparrow_forwardAn ion that is essential for muscle contraction is Ca2+. Which of the following statements about the calcium ion and muscle contractions is TRUE? Select one: a. Muscle contractions can occur whether Ca2+ concentrations are high or low. b. Ca2+ binds to the tropin-tropomyosin protein complex shifting it out of the way and allows the myosin to bind to the actin so contraction can occur. c. When Ca2+ concentrations are high, tropomyosin inhibits myosin binding and the muscle is relaxed. d. Ca2+ ions are stored in the sacroplasmic reticulum during the muscle contractions. I do not know which one isarrow_forwardPut these events that occur in skeletal muscle in the correct chronological sequence: 1. Opening of mechanically-gated ryanodine receptors (RyR) on the sarcoplasmic reticulum 2. Ca²+ binding to troponin to initiate contraction 3. Activation of voltage-gated dihydropyridine (DHP) receptor in the T-tubule 4. Na+ influx through ligand-gated ion channels on the motor end plate 4, 3, 2, 1 2, 1, 4, 3 3, 1, 2, 4 4, 3, 1, 2 3, 1, 4, 2arrow_forward
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