you are provided with counts of F1 and F2 offspring with given genders and disease phenotypes. The data are generated from an initial parental cross. One parent displays the disease phenotype and one displays the wild-type (WT) phenotype. The WT parent always has a homozygous genotype. There are three possible modes of inheritance that underlie the generation of the data. All are monogenic. They are: (i) Autosomal Recessive. (ii) Homozygous Lethal Dominant. (iii) Autosomal Dominant. One's phenotype is determined by their genotype at the disease locus and the mode of inheritance, as we have seen with the Punnett Square. In this assignment you are provided with a computer generated mode of inheritance. Your task is to perform a chi-square goodness of fit test on the F2 data and make a decision, based on your statistical analysis, as to whether you reject or do not reject the computer generated mode of inheritance as being consistent with the observed data. The mode of inheritance you are to test on the observed data is autosomal recessive. PARENTAL CROSS Parental cross: Father with disease phenotype, Mother with wild-type phenotype. F1 DATA Phenotype Gender Disease Wild-Type Male 18 23 Female 22 17 F2 DATA Phenotype Gender Disease Wild-Type Male 22 23 Female 15 20 Gender Phenotype Observed counts (O) Expected Proportions Expected Counts (E) (O-E) (O-E)^2/E Male WT 23 Male Disease 22 Female WT 20 Female Disease 15 Total 80 DegFrdm P-value

MATLAB: An Introduction with Applications

6th Edition

ISBN:9781119256830

Author:Amos Gilat

Publisher:Amos Gilat

Chapter1: Starting With Matlab

Section: Chapter Questions

Problem 1P

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Question

you are provided with counts of
F1 and F2 offspring with given genders and disease phenotypes.
The data are generated from an initial parental cross.
One parent displays the disease phenotype and one displays the wild-type (WT) phenotype.
The WT parent always has a homozygous genotype.

There are three possible modes of inheritance that underlie
the generation of the data. All are monogenic. They are:

(i) Autosomal Recessive.
(ii) Homozygous Lethal Dominant.
(iii) Autosomal Dominant.

One's phenotype is determined by their genotype at the disease locus
and the mode of inheritance, as we have seen with the Punnett Square.

In this assignment you are provided with a computer generated mode of inheritance.
Your task is to perform a chi-square goodness of fit test
on the F2 data and make a decision, based on your statistical analysis, as to whether
you reject or do not reject the computer generated mode of inheritance as being consistent
with the observed data.

The mode of inheritance you are to test on the observed data is autosomal recessive.

PARENTAL CROSS

Parental cross: Father with disease phenotype, Mother with wild-type phenotype.

F1 DATA

Phenotype

Gender Disease Wild-Type

Male 18 23

Female 22 17

F2 DATA

Phenotype

Gender Disease Wild-Type

Male 22 23

Female 15 20

Gender	Phenotype	Observed counts (O)	Expected Proportions	Expected Counts (E)	(O-E)	(O-E)^2/E
Male	WT	23
Male	Disease	22
Female	WT	20
Female	Disease	15
Total		80
					DegFrdm
					P-value

Definition Definition Measure of central tendency that is the value that occurs most frequently in a data set. A data set may have more than one mode if multiple categories repeat an equal number of times. For example, in a data set with five item—3, 5, 5, 29, 473—the mode is 5 because it occurs twice and no other value occurs more than once. On a histogram or bar chart, the element with the highest bar represents the mode. Therefore, the mode is sometimes considered the most popular option. The mode is useful for nominal or categorical data (e.g., the most common color car that users purchase), but it is problematic for continuous data because it is more likely not to have any value that is more frequent than the other.

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