Would you predict that the Claisen condensation reaction shown below would work as written? 1. LDA, –78 °C 2. MeO No Yes

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Chapter1: Chemical Foundations
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**Claisen Condensation Reaction Analysis**

Would you predict that the Claisen condensation reaction shown below would work as written?

**Reaction Setup:**

The reaction starts with a cyclohexanone compound (a six-membered cyclic ketone) on the left. 

1. Reagents: 
   - **LDA, –78 °C** (Lithium diisopropylamide, a strong base, used at low temperature)
   - The second step introduces an ester with the structure: \[ \text{MeO} \overset{\text{O}}{\vert} \text{C} \text{CH}_2 \text{CH}_2 \text{CH}_3 \]

**Expected Product:**

The product shown on the right is a β-keto ester:
- A ring structure with a ketone and an ester group separated by one CH2 group.

**Question:**

- Options:
  - No
  - Yes

Select whether you think the Claisen condensation, with the steps and conditions provided, would successfully yield the expected β-keto ester product.
Transcribed Image Text:**Claisen Condensation Reaction Analysis** Would you predict that the Claisen condensation reaction shown below would work as written? **Reaction Setup:** The reaction starts with a cyclohexanone compound (a six-membered cyclic ketone) on the left. 1. Reagents: - **LDA, –78 °C** (Lithium diisopropylamide, a strong base, used at low temperature) - The second step introduces an ester with the structure: \[ \text{MeO} \overset{\text{O}}{\vert} \text{C} \text{CH}_2 \text{CH}_2 \text{CH}_3 \] **Expected Product:** The product shown on the right is a β-keto ester: - A ring structure with a ketone and an ester group separated by one CH2 group. **Question:** - Options: - No - Yes Select whether you think the Claisen condensation, with the steps and conditions provided, would successfully yield the expected β-keto ester product.
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