Would you predict that the Claisen condensation reaction shown below would work as written? 1. LDA, –78 °C 2. MeO No Yes

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
icon
Related questions
Question

what would be the answer? 

**Claisen Condensation Reaction Analysis**

Would you predict that the Claisen condensation reaction shown below would work as written?

**Reaction Setup:**

The reaction starts with a cyclohexanone compound (a six-membered cyclic ketone) on the left. 

1. Reagents: 
   - **LDA, –78 °C** (Lithium diisopropylamide, a strong base, used at low temperature)
   - The second step introduces an ester with the structure: \[ \text{MeO} \overset{\text{O}}{\vert} \text{C} \text{CH}_2 \text{CH}_2 \text{CH}_3 \]

**Expected Product:**

The product shown on the right is a β-keto ester:
- A ring structure with a ketone and an ester group separated by one CH2 group.

**Question:**

- Options:
  - No
  - Yes

Select whether you think the Claisen condensation, with the steps and conditions provided, would successfully yield the expected β-keto ester product.
Transcribed Image Text:**Claisen Condensation Reaction Analysis** Would you predict that the Claisen condensation reaction shown below would work as written? **Reaction Setup:** The reaction starts with a cyclohexanone compound (a six-membered cyclic ketone) on the left. 1. Reagents: - **LDA, –78 °C** (Lithium diisopropylamide, a strong base, used at low temperature) - The second step introduces an ester with the structure: \[ \text{MeO} \overset{\text{O}}{\vert} \text{C} \text{CH}_2 \text{CH}_2 \text{CH}_3 \] **Expected Product:** The product shown on the right is a β-keto ester: - A ring structure with a ketone and an ester group separated by one CH2 group. **Question:** - Options: - No - Yes Select whether you think the Claisen condensation, with the steps and conditions provided, would successfully yield the expected β-keto ester product.
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Group 2 Elements
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Chemistry
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY