Workshop 3 Topic: Bio-isosteres and derivatives 1. Carefully examine the below drug, and suggest two bio-isosteric modifications for the heterocyclic ring in furosemide without changing activity. 00 0 H₂N S O b OH a ZI N N C H N CI Furosemide Ring name Ring Physicochemical properties P NI ZI N e Suitability as bio-isosteres

Workshop 3 Topic: Bio-isosteres and derivatives 1. Carefully examine the below drug, and suggest two bio-isosteric modifications for the heterocyclic ring in furosemide without changing activity. 00 0 H₂N S O b OH a ZI N N C H N CI Furosemide Ring name Ring Physicochemical properties P NI ZI N e Suitability as bio-isosteres

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter23: Amines

Section: Chapter Questions

Problem 23.58P

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