Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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Workshop 3
Topic: Bio-isosteres and derivatives
1. Carefully examine the below drug, and suggest two bio-isosteric modifications for
the heterocyclic ring in furosemide without changing activity.
00
0
H₂N
S
O
b
OH
a
ZI
N
N
C
H
N
CI
Furosemide
Ring name Ring Physicochemical
properties
P
NI
ZI
N
e
Suitability as bio-isosteres
expand button
Transcribed Image Text:Workshop 3 Topic: Bio-isosteres and derivatives 1. Carefully examine the below drug, and suggest two bio-isosteric modifications for the heterocyclic ring in furosemide without changing activity. 00 0 H₂N S O b OH a ZI N N C H N CI Furosemide Ring name Ring Physicochemical properties P NI ZI N e Suitability as bio-isosteres
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