Workshop 3 Topic: Bio-isosteres and derivatives 1. Carefully examine the below drug, and suggest two bio-isosteric modifications for the heterocyclic ring in furosemide without changing activity. 00 0 H₂N S O b OH a ZI N N C H N CI Furosemide Ring name Ring Physicochemical properties P NI ZI N e Suitability as bio-isosteres

Workshop 3 Topic: Bio-isosteres and derivatives 1. Carefully examine the below drug, and suggest two bio-isosteric modifications for the heterocyclic ring in furosemide without changing activity. 00 0 H₂N S O b OH a ZI N N C H N CI Furosemide Ring name Ring Physicochemical properties P NI ZI N e Suitability as bio-isosteres

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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A ALEKS - Alec Nema - Learn G Arrange the compounds below ir x A www-awu.aleks.com/alekscgi/x/Isl.exe/1o_u-lgNslkr7j8P3jH-IvUrTNdLZh5A8CnG03PBGuXr8iCPa7ZMmym9pTWPGPMQBZuhqGO-ia6eFgZ0OQdKyhK7Uw7cw-OpH... ☆ : Apps Sprouts Academy. 9 Online Tutoring C 400 Request Heade... Q Weather & Soil CH.. O CHEMICAL BONDING Predicting the relative ionic character of chemical bonds Alec V Arrange the compounds below in decreasing order of the jonic character of the bonds in them. That is, pick 1 for the compound with the most ionic bonds, pick 2 for the compound with the next most ionic bonds, and so on. jonic character compound of bonds dla CaCl, (Choose one) ▼ Cl, (Choose one) ▼ SiCl, (Choose one) AICI, (Choose one) ▼ Explanation Check O 2020 McGraw-Hill Education. All Rights Reserved. Terms of Use | Privacy I Accessibi 3:5 12/ P Type here to search (15 II
Please provide the IUPAC name (only) for the compound that best represents the spectroscopic data here: • Molecular formula: C4H100 Important IR data (cm 1): 3280 (broad); 2910-2950 (many); 1053 • All 'H NMR data shown as x.xx ppm (splitting), integration. 1.23 ppm (t), 3 1.23 ppm (d), 3 "-OH" 1.46 ppm (m), 2 4.03 ppm (m), 1 5. PPM
2. Compound A, C;H100 , is one of the basic building blocks of nature. All steroids and many other naturally occuring compounds are built from compound A. Spectroscopic analysis of A yields the following information: IR: 3400 cm-'; 1640 cım- IH NMR: 1.63 & (3 H, singlet); 1.70 ô (3 H, singlet); 3.83 6 (1 H, broad singlet); 4.15 8 (2 H, doublet, j = 7 Hz); 5.70 ô (1 H, triplet, ) = 7 Hz) (a) How many double bonds and/or rings does A have? (b) From the IR spectrum, what is the identity of the oxygen-containing functional group? (c) What kinds of protons are responsible for the NMR absorptions listed ? (d) Propose a structure for A.
Reaction of acetic acid, CH3CO2H, with isotopically labeled CH318OH and catalytic sulfuric acid gives: 180 A) CH;COCH; + H2O CH;C "OCH; + H,0 180 II C) CH;COCH3 + H¿®O D) equal amounts of A and B
Exercice 1 Cis-jasmone K is an important intermediate in perfumery. a) What is its name according to IUPAC nomenclature? b) Does it have mesomeric forms? If so, which ones? c) Cis-jasmone K can accept the molecule L as a precursor. How can it be converted from L to K? What mechanism would you suggest? Can other isomeric compounds of K be formed? If so, which ones? CH 3 H3C S H K H H₂C. OH L H CH3 H
(c) 1 Unambiguously identify the structures of the following major organic product(s), starting materials (reactants), or reagents for the following reactions Draw all possible stereoisomers (") where necessary; double-dagger (1) must show two products: (b)* d)* (a) OH o. I (excess) R I. HO & OH OH H НО OH H₂O (excess) [H"] [H')/-(H₂O) [H1/H₂01 Br₂/H₂O* pH =6
H ll PTSCluster.pptcap.loc hapter X MasteringChemistry: Chapter 4 A X ew?offset3Dnext&assignmentProblemID=170497302 Part A What is the IUPAC name for the molecule shown? Enter the IUPAC name for the molecule. - View Available Hint(s)
3. What is the main product for each of the following reactions? (a) p-Methylanisole + CH3CH₂COCI, AICI3 -> ? (b) Toluene + Br₂, light, then CH3CH₂COCI, AICI 3 -> ? -> ? (c) Acetophenone + CH³CH₂CI, AICI3, then Br₂, Fe -----> ? (d) Styrene + CH3CH₂COCI AICI3, then Br2, Fe (e) Benzene + 1-chloro-2,2-dimethylpropane, AlCl3 ----> ? (f) Benzene + 3-phenyl-1-propene, H₂SO4, heat > ? (g) Toluene + 1-phenyl-3,3-dimethyl-2-butanol, H₂SO4, heat (h) Benzene + HCOCI, AICI3 then 1-chlorobutane, AlCl3 - ? ‒‒‒‒
ching and lea X + 2-cnow-owl.cengagenow.com/ilrn/takeAssignment/takeCovalentActivity.do?locato Draw the organic product(s) of the following reaction. NaNH, I NH3(I) CH3 H₂C-C-CEC- CH3 O • You do not have to consider stereochemistry. Include cationic counter-ions, e.g., Nat in your answer, but draw • If no reaction occurs, draw the organic starting material. Separate multiple products using the + sign from the drop-dowr ● ● ***I ChemDoodle ▼ [F
Give the major organic product(s) of the following. Include stereochemistry when applicable. 1) Nal Br a) 2) NaCN, acetone 1) NaOC(CH3)3, heat d Br 2) BH₂ THF; 3) H,O,, NaOH(aq) b) c) d) c) 2) KOC(CH3)3, heat Copyright University of California Merced 2022 Br 1) NaOH, heat 2) MCPBA 1) KOC(CH3)3, heat 2) H3O+