Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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will someone help me understand the concept

Why does DNA polymerase require a primase in order to begin DNA replication? O DNA replication requires a 3'-OH to act as nucleophile and it is provided by the RNA primer produced by primase DNA replication requires a 2'-OH to act as nucleophile and it is provided by the RNA primer produced by primase O Primase is required only for lagging strand synthesis because of the replication fork and the 5'>3' directionality of DNA polymerase O Primase is required only for leading strand synthesis because of the replication fork and the 5'>3' directionality of DNA polymerase
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Transcribed Image Text:Why does DNA polymerase require a primase in order to begin DNA replication? O DNA replication requires a 3'-OH to act as nucleophile and it is provided by the RNA primer produced by primase DNA replication requires a 2'-OH to act as nucleophile and it is provided by the RNA primer produced by primase O Primase is required only for lagging strand synthesis because of the replication fork and the 5'>3' directionality of DNA polymerase O Primase is required only for leading strand synthesis because of the replication fork and the 5'>3' directionality of DNA polymerase
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