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Why does DNA polymerase require a primase in order to begin DNA replication? O DNA replication requires a 3'-OH to act as nucleophile and it is provided by the RNA primer produced by primase

Why does DNA polymerase require a primase in order to begin DNA replication? O DNA replication requires a 3'-OH to act as nucleophile and it is provided by the RNA primer produced by primase

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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Why does DNA polymerase require a primase in order to begin DNA replication? O DNA replication requires a 3'-OH to act as nucleophile and it is provided by the RNA primer produced by primase DNA replication requires a 2'-OH to act as nucleophile and it is provided by the RNA primer produced by primase O Primase is required only for lagging strand synthesis because of the replication fork and the 5'>3' directionality of DNA polymerase O Primase is required only for leading strand synthesis because of the replication fork and the 5'>3' directionality of DNA polymerase
Transcribed Image Text:Why does DNA polymerase require a primase in order to begin DNA replication? O DNA replication requires a 3'-OH to act as nucleophile and it is provided by the RNA primer produced by primase DNA replication requires a 2'-OH to act as nucleophile and it is provided by the RNA primer produced by primase O Primase is required only for lagging strand synthesis because of the replication fork and the 5'>3' directionality of DNA polymerase O Primase is required only for leading strand synthesis because of the replication fork and the 5'>3' directionality of DNA polymerase
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