Why can imputation lead to bias in GWAS studies?

Q: How can RNA sequencing (RNA-Seq) and microarrays in Transcriptome analysis find disease genes?

A: Researchers can describe the transcriptional activity (coding and non-coding), concentrate on a…

Q: What is the correct citation for this article https://doi.org/10.1016/j.pep.2018.03.006 based on the…

A: A citation is a reference to the knowledge source that you used in your analysis. In your job, if…

Q: How can the concept ofrecombination frequency beused in genetic mapping?

A: Recombination is a process of exchange of genetic material between two different organisms.…

Q: What is a filtered word test?

A: A Screening test to asses central auditory processing disorder in children of 5-11 years, consists…

Q: Why should researchers use random assignmnet?

A: A random assignment can be defined as an experimental technique that is used for assigning plants,…

Q: Briefly explain how genes affecting a polygenic characteristic are located with the use of QTL…

A: Polygenic inheritance is an exception to Menders laws. Polygenic traits have wide variation in them.…

Q: What is meant by Genetic Information NondiscriminationAct (GINA) ?

A: Genetics can be defined as the branch of biology which is concerned with the study of genes, genetic…

Q: Discuss theh type of information that genome-wide association studies can provide

A: DNA is the genetic material in most living organisms. It is the information hub of the cell that…

Q: Determine the experimental design that makes the difference between the given two modes of action at…

A: The antisense ribonucleic acid is a type of single-stranded ribonucleic acid molecule that binds to…

Q: What is Marker Assisted Breeding?

A: Marker assisted selection can be denoted as using of DNA markers which is tightly linked to loci of…

Q: what is dosage compensation.?

A: Sex of an organism in various species depends on the type and number of sex chromosomes. In species…

Q: Why are appropriate transducer orientation and image standardization important in vascular…

A: Importance of transducer orientation in Vascular Sonography: *In order to get an exact image, the…

Q: s th

A: Answer-- Meselson and Stahl experiment use N15 in E.coli by density gradient centrifugation.This…

Q: What are the advantages of normalizing against a reference gene in qPCR?

A: PCR stands for Polymerase Chain Reaction, and it is a widely used method that allows us to make many…

Q: Why ELSI Program is important for issues arising from the HGP ?

A: HGP stands for human genome project. It is an international scientific research project. This…

Q: Genotyping of few SNPs in many patients?

A: SNP's stands for Single Nucleotide Polymorphism which usually occurs due to some point mutation. Any…

Q: In a cotransduction experiment involving P1, the cotransductionfrequency was 0.53. How far apart are…

A: Transduction is the process of the transferring foreign DNA into the host cell by viral vector. T4…

Q: What is abiogenesis? Why the Urey-Miller experiment so important? How did the experiment work?…

A: Introduction :- According to the theory of abiogenesis, the earliest life forms produced were…

Q: What is high throughput screening used for?

A: High throughput screening:   It is a scientific method of drug discovery. With the use of robotics,…

Q: Among different species, describe three distinct mechanisms foraccomplishing dosage compensation.

A: Dosage compensation is a mechanism by which organisms equalize the gene expression between different…

Q: Lab Data G1 G2 G3 G4 G5 Released Тypіca 250 166 259 372 521 851 Carbonaria 750 308 254 234 210 199…

A: Gentotype and phenotype of an organism are related to the genetic material of an organism. The…

Q: What is a mouse model for human disease?

A: Humans are the multicellular eukaryotic organism belonging to the kingdom Animalia and class…

Q: Why is QTL mapping in human genetic diseases important?

A: Human genetic disease or hereditary disorders is an illness brought about by changes in an…

Q: How can AI and ML be used to identify biomarkers?

A: AI stands for Artificial Intelligence while ML stands for Machine Learning. Machine learning is a…

Q: a с STARR-seq construct ORF hkCP or dCP Enhancer ORF hkCP S2 STARR-seq 1,822 4,134 (32%) 3,586 pA…

A: The sets of genes in our genome can be broadly divided into 2 groups; Housekeeping genes and…

Q: How is complementation a useful technique in understanding allelism and gene function

A: When two varieties of an entity have separate homozygous recessive mutations, if they both display…

Q: How can linkage disequilibrium mapping sometimes provide a much higher resolution of gene location…

A: Linkage analysis rely on co inheritance of functional polymorphism, In linkage analysis, there are…

Q: How SNPs can be detected and used for diagnosis and treatmentof disease ?

A: The study of genomes' architecture, functioning, development, sequencing, and modification is the…

Q: Why are maternal effect genes so difficult to identify via mutant analysis?

A: Introduction :- In an offspring , the genes are contributed by both of the parents but the mother…

Q: illustrate several applications of the chi-square test pertinent to genetics.

A: A chi-square test (X2) is a statistical procedure which is used in decision making in case of…

Q: Explain selectable and non selectable markers for the detection of transformants?

A: Marker is a gene used to conform whether a nucleic acid sequence has successfully been inserted into…

Q: Various kinds of biochemical events may explain why some disease alleles are dominant?

A: Answer: Introduction: Genes are structural and functional unit of cell. Mutations in genes  may lead…

Q: Explain how researchers identify QTLs by establishingbackcross lines and then fine-mapping the QTLs…

A: Gene expression microarrays allow the quantification of transcript accumulation for plenty of genes…

Q: Explain the multiple testing problem of GWAS - why do we need such a small p-value to achieve…

A: Imagine you're flipping a coin a bunch of times. If you only flip it once, getting heads might not…

Q: Define the historical significance of Southern blotting ?

A: DNA profiling is the process of determining an individual's unique DNA pattern. DNA profiling can…

Q: What class of genes is used in MLST analyses?

A: MLST refers to multilocus sequence typing. MLST involves higher frequency of recombination in…

Q: What is the major difference between generalized transductionand transformation?

A: TRANSDUCTION:- Is the process  by which DNA is transferred from one bacterium to another by a virus…

Q: People with severe depression, mild depression, or no depression are included in GWAS research. Why…

A: A genome-wide association study (GWAS) is an approach used in genetics research to associate…

Q: Explain how COVID-19 can be detect using molecular based

A: Given: Need to find how the COVID-19- can be detected using molecular based technology. Coronavirus…