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- what are the short comings of randomized clinical trials ?What are the three types of study designs used in GWAS? Provide a specific example of a study performed in research using one of these methods. Why was this study design chosen over the other two methods?Why is QTL mapping in human genetic diseases important?
- What is the primary advantage to using a chimeric mouse in animal trials of a new drug and what are two ways that this approach might lead to inaccurate data?How does high throughput screening work?Discuss the different designs for collecting the information desired in a Randomised Controlled Trial (RCT).
- Randomized assignment (allocation) to treatment and control groups is primarily used to reduce which source of bias? a) Recall bias b) Selection bias c) Berkson's bias d) Information biasDescribe some sources of potential bias in biomedicalresearch. What are some ways of minimizing such bias?Identify a possible advantage and a possible disadvantage of a genetic test that would identify genes in individuals that increase their probability of having Alzheimer’s disease later in life.
- What is Long QT Syndrome? What are three genes associated with Long QT Syndrome?What is metrology? How does metrology relate to Analytical Biotechnology? Relate the terms error and uncertainty to the concepts of precision and accuracy. What are the major parameters of instrumental response?What is the purpose of randomization in a randomized controlled trial? a. To ensure that there are fewer adverse effects b. To ensure that participants are unaware as to whether they are receiving the medicine or the placebo c. To ensure that participants in the treatment group and those in the pacebo (or control) group are as similar as possible when the study begins d. To ensure that participants in the trial are representative of the target population