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Why are receptors for steroid hormones located inside the cell instead of being on the cell membrane?

Why are receptors for steroid hormones located inside the cell instead of being on the cell membrane?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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**Why are receptors for steroid hormones located inside the cell instead of being on the cell membrane?** Steroid hormones are lipophilic, meaning they can easily pass through the lipid bilayer of the cell membrane. This characteristic allows them to reach their intracellular receptors directly. Unlike peptide hormones that bind to membrane receptors, steroid hormones do not need an external receptor to transmit signals into the cell. Once inside, they bind to specific receptors in the cytoplasm or nucleus, influencing gene expression and directly affecting cellular functions. This mechanism allows for a more direct and prolonged effect on the target cells.
Transcribed Image Text:**Why are receptors for steroid hormones located inside the cell instead of being on the cell membrane?** Steroid hormones are lipophilic, meaning they can easily pass through the lipid bilayer of the cell membrane. This characteristic allows them to reach their intracellular receptors directly. Unlike peptide hormones that bind to membrane receptors, steroid hormones do not need an external receptor to transmit signals into the cell. Once inside, they bind to specific receptors in the cytoplasm or nucleus, influencing gene expression and directly affecting cellular functions. This mechanism allows for a more direct and prolonged effect on the target cells.
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