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- The ribosome is the target for many important antibiotics. These drugs must discriminate between bacterial and eukaryotic ribosomes to achieve drug specificity and toxicity. For the two common antibiotics below, what is their mechanism of action and why are they more toxic to bacteria than eukaryotes? a) Tetracycline b) ErythromycinWhich statement among A-D is false regarding bacterial toxins? A) O Hemolysıns are cell membrane disrupters that can rupture red blood cells. B) O Second mesengar pathway disrupters like cholera toxin produces a debilitating respiratory condition of the lungs. C) O Shiga toxin, tetanus toxin, and hemolysins are all types of exotoxins. D) O Superantigens elicit a hyperactive response by the immune system and can lead to shock. E) O None are false, A-D are all true statements.Why are Archaea resistant to penicillin?
- Which bacteria produce β-lactamase enzyme which is resistant to penicillin and why?Chlamydia are pathogenic bacteria that must be grown within a eukaryotic host cell. They rely on the host cell for many nutrients, including nucleotides, lipids, and amino acids. It is thus no surprise that when grown in co-culture with a host depleted of any of these metabolites, chlamydial growth declines. However, high levels of certain amino acids also inhibit chlamydial growth. Specifically, the amino acids leucine, isoleucine, methionine, and phenylalanine slow down the growth by inhibiting the amino acid transporter called BrnQ. On the other hand, if valine is present in the medium these amino acids have no effect on BrnQ. Discuss how this might be possibleWhat is the mechanism that makes Bacteria resistant to Beta-lactams
- Under cellular conditions, dATP can be oxidized to its 2-hydroxy form, which is a substrate for an enzyme that converts 2-OH-dATP to 2-OH-dAMP + PPi. Explain why compounds that inhibit the activity of this enzyme would be eff ective anticancer agents.Because elemental poisons, such as heavy metals, cannot be furtherdegraded even by microbes, what is a possible fate of these metals?What are some of the disadvantages of using natural penicillin for treatment of infections?