Which statement is TRUE regarding the DNA ligase mechanism?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Which statement is TRUE
regarding the DNA ligase
mechanism?
A)the last step of the reaction
proceeds through a tetrahedral
intermediate
B)ATP is an obligate donor of an
adenylyl group in the reaction of
the bacterial enzyme
C)The high energy of a
phosphoanhydride bond is
conserved in the reaction
D)The phosphate of the AMP
product is linked to the 3'-OH of
the ribose
E)ATP is required as an energy
source to overcome the transition
state barrier
Transcribed Image Text:Which statement is TRUE regarding the DNA ligase mechanism? A)the last step of the reaction proceeds through a tetrahedral intermediate B)ATP is an obligate donor of an adenylyl group in the reaction of the bacterial enzyme C)The high energy of a phosphoanhydride bond is conserved in the reaction D)The phosphate of the AMP product is linked to the 3'-OH of the ribose E)ATP is required as an energy source to overcome the transition state barrier
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