Which of the following is/are true for sickle-cell anemia? I. It results from a point mutation on the beta sub-unit which results to the amino acid substitution of V with E. II. The sickle-shaped RBC's are vaso-occluded in the capillaries resulting to damage in various internal organs. TIt. Hemoglobin precipitates when deoxygenated, resulting to the distortion in the shape of the thrombocytes. Select the correct response: Il only I, ll, and Ill ll and III I only Ill only l and lI

D. ABO and Rh Blood Typing Name the antigens present on the RBCs and the antibodies present in plasma of each blood type. A Antigens on RBCs Antibodies in Plasma B AB Based on what you know about antigens and antibodies, what blood type is the universal donor? Explain. What blood type is the universal recipient? Explain. E. Hematocrit . Define hematocrit. What is the anticoagulant used in this type of blood test? Ron has a hematocrit of 47%. Is this within the normal range? (yes/no) Janey has a hematocrit of 58%. Is this within the normal range? (yes/no) F. Hemoglobin Content and Coagulation Time . Do the hematocrit and hemoglobin content of blood measure the same thing? What is the importance of coagulation time? Would a hemophiliac have an above or below normal coagulation time? Explain.

10. Calculate the dose of vincristine in mLs for a 4-yr-old with leukemia weighing 37 lb and is 97 cm tall. The dose required in 2 mg/m2 and the drug comes in 1 mg/mL concentration.

1. Identify the two most common types of genetic disorders called hemophilia. Explain how each of the two types of hemophilia results in impaired hemostasis.  2. Explain how the endocrine system contributes to the hemostasis of blood oxygen levels.