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- present the chemical mechanism of the HIV protease. Discuss the mode of action of some inhibitors of this enzyme.Palivizumab is a humanized monoclonal anitbody for the prohylaxis of resporatory diseases caused by respiratory syncytical virus (RSV) Researches added palivizumab ( or anitbody 101F as positive control) to RSV prior to incubation with human cells. Based on what you learned about palivizumab what does the data recorded below demonstrate about palivizumab mechanism of action?A cell is infected with an HIV mutant that results in very little virus being released into the medium that is used to grow the cultured cells. Upon electron microscopy it is noted that the membrane of the infected cell is idenitcal in appearance to a cell that has not been infected. In addition there is relatively little viral RNA in the cells and relatively few proviruses in the cellular genome when compared to a non-mutant HIV infection. Which of the following proteins is most likely mutated? Multiple Choice gag reverse transcriptase vif vpu
- Researchers studying the SARS-CoV-2 virus, also known as COVID-19, have found that the virus is able to circumvent its host cell's normal defenses by leaving the cell via its lyso- somes rather than its normal secretory vesicles, as illustrated in the figure below. endoplasmic reticulum nucleus disrupted lysosomal functions Entry and egress of the SARS-CoV-2 virus A Golgi complex Which of the following best explains their findings? B lysosome (deacidified) С lysosome (acidified) B-coronavirus normal biosynthetic pathway egress via lysosomal trafficking SARS-CoV-2 inhibits lysosomes of its host cells by decreasing the pH within them. SARS-CoV-2 activates lysosomes of its host cells by decreasing the pH within them. SARS-CoV-2 activates lysosomes of its host cells by increasing the pH within them. D SARS-CoV-2 inhibits lysosomes of its host cells by increasing the pH within them.What low molecular weight protiens are produced by a hot cell in response to a viral infection that protects a pre-infected cell from a viral infectedExplain the role receptor-mediated endocytosis (RME) plays in virus replication (lytic cycle).
- Before development of a vaccine against this microbe, thedisease it caused accounted for two-thirds of bacterial meningi-tis cases during the first year of life but is still the number oneleading cause of mental retardation in patients who survive seri-ous disease due to permanent central nervous system disorders.What is the microorganism?(a) Haemophilus influenzae type B(b) Haemophilus influenzae type A(c) Neisseria meningitidis(d) Streptococcus pneumoniae(e) Listeria monocytogenesAn ade+ arg+ cys+ his+ leu+ pro+ bacterial strain is knownto be lysogenic for a newly discovered phage, but the siteof the prophage is not known. The bacterial map isleucysarghisadeproThe lysogenic strain is used as a source of the phage, andthe phages are added to a bacterial strain of genotypeade- arg- cys- his- leu- pro-. After a short incubation,samples of these bacteria are plated on six differentmedia, with the supplementations indicated in thefollowing table. The table also shows whether colonieswere observed on the various media.PresenceMedium Ade Arg Cys His Leu Pro of colonies1 - + + + + + N2 + - + + + + N3 + + - + + + C4 + + + - + + N5 + + + + - + C6 + + + + + - NNutrient supplementation in medium(In this table, a plus sign indicates the presence of anutrient supplement, a minus sign indicates that asupplement is not present, N indicates no colonies, and Cindicates colonies present.)a. What genetic process is at work here?b. What is the approximate locus of the prophage?Which of the following is an example of virus-encoded molecules modifying signal transduction pathways to promote replication? Production of a small subgenomic RNA in flavivirus-infected cells Degradation of Xrn1 in poliovirus-infected cells Herpes simplex virus protein that blocks pre-mRNA splicing Poliovirus cleavage of nuclear export proteins