When rotenone is added to actively respiring bovine mitochondria, the ratio of NADH to NAD+ increases but the FADH2 to FAD ratio remains unchanged. a. What step in the system is being inhibited by rotenone? b. What would be the effect of rotenone on pyruvate oxidation to CO2? ____________________ Why?

When rotenone is added to actively respiring bovine mitochondria, the ratio of NADH to NAD+ increases but the FADH2 to FAD ratio remains unchanged. a. What step in the system is being inhibited by rotenone? b. What would be the effect of rotenone on pyruvate oxidation to CO2? ____________________ Why?

Principles Of Pharmacology Med Assist

6th Edition

ISBN:9781337512442

Author:RICE

Publisher:RICE

Chapter22: Medications Used For Gastrointestinal System Disorders

Section: Chapter Questions

Problem 10RQ

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Question

When rotenone is added to actively respiring bovine mitochondria, the ratio of NADH to NAD⁺ increases but the FADH₂ to FAD ratio remains unchanged.

a. What step in the system is being inhibited by rotenone?

b. What would be the effect of rotenone on pyruvate oxidation to CO₂?

____________________ Why?

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