When researchers at the Best Southern University tested the Drug X (from a commercial source), it failed to lower blood cholesterol levels in mice. They emailed Dr. Meg A'Brain for some clarifications about the conditions of the Drug X administration; specifically, they wanted to know:Amount of Drug X administeredDuration of administrationAge, gender and number of miceMethod of administration (mixed with food or in water, i.v. or i.p. injected)Dr. Meg A'Brain said, "Of course, please see attached publication from my lab" and attached the paperDolt Colt & Meg A'Brain, Journal of Irreproducible Results (2018), 666, 1234-1240 Here is the information from the Methods section of the paper.Drug X was dissolved in DMSO and administered to male mice for 7 days. After 7 days, blood was withdrawn from the tail vein and cholesterol levels measured using a kit. The drug was administered for 7 days. What is this publication lacking? Question 4 options: Replicability Reproducibility Generalizability Translatability Rigor Transparency

Replicability -“Performing the experiment again and new data is collected”. Reproducibility -…

Answered: When researchers at the Best Southern…

Principles Of Pharmacology Med Assist

6th Edition

ISBN:9781337512442

Author:RICE

Publisher:RICE

Chapter7: Drug Sources, Schedules, And Dosages

Section: Chapter Questions

Problem 19RQ

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When researchers at the Best Southern University tested the Drug X (from a commercial source), it failed to lower blood cholesterol levels in mice. They emailed Dr. Meg A'Brain for some clarifications about the conditions of the Drug X administration; specifically, they wanted to know:

Amount of Drug X administered
Duration of administration
Age, gender and number of mice
Method of administration (mixed with food or in water, i.v. or i.p. injected)

Dr. Meg A'Brain said, "Of course, please see attached publication from my lab" and attached the paper
Dolt Colt & Meg A'Brain, Journal of Irreproducible Results (2018), 666, 1234-1240

Here is the information from the Methods section of the paper.

Drug X was dissolved in DMSO and administered to male mice for 7 days. After 7 days, blood was withdrawn from the tail vein and cholesterol levels measured using a kit. The drug was administered for 7 days.

What is this publication lacking?

Question 4 options: