When IkB is phosphorylated, NFKB is free to initiate gene expression promoting protein degradation. Studies suggest this pathway "exacerbates" in skeletal muscle. Aerobic exercise at a relatively low intensity may TNF-a. High intensity training may acutely increase TNF-a but may lower it long- term. Several studies have shown that both aerobic and resistance training may reduce inflammatic (TNF-a) and protein degradation (NFKB ) and reduce in response exercise. More specifically, acute bouts of exercise activate NFKB early in training while long-term training may down-regulate NFKB, promoting. Endurance training results in

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