When anisole is treated with excess bromine, the reaction gives a product which shows two singlets in 1H NMR. Draw the product.

Fill in the missing reagents a-e in the following scheme:

Draw mechanism using pyradine as a base in the intial step Draw the mechanism using pydradine as a general base Draw the mechanism using pyradine as a nucleophilic catalyst Draw the mechanism using nucleophilic catalysis and using acetate as a general base H3C ROH ་ ་ CH3 N H3C -R

Mechanism of azide synthesis: Step 1: Nucleophilic substitution of alkyl halide with sodium azide to form an alkyl azide. Step 2: Reduction of alkyl azide with a reducing agent such as sodium borohydride or lithium aluminum hydride to form an alkylamine. Mechanism of alkylation of ammonia: Step 1: The alkyl halide undergoes a nucleophilic substitution reaction with ammonia gas to form an intermediate alkylamine. Step 2: The intermediate alkylamine is deprotonated by the catalyst to form the final alkylamine.

Select the best reagents to produce the product shown as the major or exclusive product. OH ? O KOC(CH3)3 O (heat/H2SO4) or (NaOEt) O heat/H2SO4 O CH3CO2H O NaOEt

Propose a synthetic route by clearly indicating the reagents needed and the intermediate products formed. OH Ď Show Transcribed Text

Choose the best reagents to complete the following reaction. $ H₂O OH $ < OH A B C D E NaOH H₂O H2, Raney nickel TSOH, H₂O (CH2OH)2, TSOH Done

Propose an efficient synthesis for the follwoing transformation. You may use any reagent you need. You do need to show mechanism and products for each individual reaction.

The anticoagulant Warfarin can be synthesized by a conjugate addition (Michael addition) reaction as shown below: a) Propose a mechanism for the reaction starting from the enolate shown below. You can assume water is present for any proton transfers needed.b) We saw that the keto tautomer is normally preferred over the enol tautomer, however, the enol tautomer is present in the final product (Warfarin) and that is the more stable tautomer in this case. Why do you think the enol tautomer is more stable? Hint: consider the molecule as a whole.

Draw the major product of the following reaction sequence. OH H2CrO4 HO NaBH4 H*/H20 ELOH он H3C* но