What would be the stereospecific product of the following substrate. substrate (ant-staggered) 180" Dihedral angle between Cl and H= abond constantly rotates same substrate (explised) base E2 ? A) B) 6 ar ar Z is the only product Es the only product Z is the major product and E is the minor product Es the minor product and 2 is the manor product

Q18. Predict the major product from the reaction shown below and draw the curved arrow mechanism for the electrophilic chlorination. OMe Cl2, FeCl3 ထု OMe

Determine if the conditions in each reaction below will favor an SN2 or an E2 mechanism as the major pathway. Then draw the major product that results.

(There was an extra carbon, so those extras were whited out)

4. Predict the products for the following enolate reactions. a) LDA b) MeBr a) 0.95 equiv LDA RT b) MeBr a) 1.1 equiv LDA -78 C b) c) H3O+ H

Please predict the outcome of each E2 elimination reaction: Hint: Assume it can only occur if the beta-hydrogen atom is anti-periplanar to the leaving group. Type you answer as a letter: A, B, or F. Problem 1: Answer to Problem 1: D A DH H H D CH3 "CI CH3 CH3 CH3 anti- ***** E2 elimination H H B E ? CH3 CH3 CH3 C F H CH3 CH3 CH3

1) Which substrate would react most rapidly in an SN2 reaction? O CH3CH2CH2CH=CHBr OCH2=CHCH2CH2CH2Br CH3CH2CH=CHCH2Br BrCH2CH2CH=CHCH3 OCH3CHBRCH=CHCH3

2. Complete one of the SN2 reactions below that occurs with an enolate nucleophile. 1) LDA, -78 °C a) 2) Br 1) LDA, -78 °C CB Chistry Sto b) Chemistry Steps 2) c) 1) LDA, -78 °C 2) Br 3) Br₂, H+ Ⓒ3) Chemistry Ste 4) Pyridine CS Chemistry Steps 1) LDA, -78 °C 1) NaH ? e) ? 2) Chemistry Steps 2) Br Chemistry Steps Chemistry Steps Chemistry Steps Chemistry Steps

Draw the full mechanism  for the following transformation