
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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Transcribed Image Text:mple. B-bromopyridine undergoes efficient exchange with n-b
basic tetrahydrofuran as solvent, and at this temperature, the alk
ly addition to the ring occurs, although the exchange can be c
as typi
peratures.9
what
mecaniss mm
Br
n-Buli
PHCN
Et,0, -78 °C then aq HCI
Ph
61%
N.
n also be prepared from bromo-pyridines at 0 °C via exchang
TMSCH,Li) and lithium dimethylaminoethoxide (LIDMAE)
react selectively a C-2) and from chla
Metal-halogen exchange with 2,5-dibrome
d 2,3-dibromopyridine
uiuo metallation, 102
Ilurtrates its trapping w
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