What is the multiple testing problem? Why is the Bonferroni adjustment conservative for GWAS data analysis? Suppose you are conducting two parallel and identical GWA studies (using the Affymetrix 500k GeneChip platform), one study in a European population and one in an African population. For which study would the Bonferroni adjustment be more conservative - European or African? Why?

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What is the multiple testing problem? Why is the Bonferroni adjustment conservative for GWAS data
analysis? Suppose you are conducting two parallel and identical GWA studies (using the Affymetrix
500k GeneChip platform), one study in a European population and one in an African population. For
which study would the Bonferroni adjustment be more conservative - European or African? Why?
Transcribed Image Text:What is the multiple testing problem? Why is the Bonferroni adjustment conservative for GWAS data analysis? Suppose you are conducting two parallel and identical GWA studies (using the Affymetrix 500k GeneChip platform), one study in a European population and one in an African population. For which study would the Bonferroni adjustment be more conservative - European or African? Why?
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