Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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What is the mechanism for the following reaction? 

### Synthesis of Indole Derivative

This illustration represents a chemical reaction involving an indole derivative.

1. **Reactants:**
    - **First molecule (left side):**
        - The structure contains a benzene ring fused to a five-membered ring with a double bond and an OH (hydroxyl) group attached.
    - **Second molecule (middle):**
        - Comprises an amide group (NH₂) with a carbonyl group (C=O) attached.
    
2. **Reaction:**
    - These molecules react together, as indicated by the "+" and the arrow, to form a new product.

3. **Product:**
    - **Final molecule (right side):**
      - The benzene ring is still fused to the five-membered ring.
      - A NH₂ (amine) group replaces the initial OH group.

This reaction shows the transformation of a hydroxyl group to an amine group within an indole framework, showcasing a common type of organic synthesis used in pharmaceutical chemistry and other chemical industries involving indole derivatives.
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Transcribed Image Text:### Synthesis of Indole Derivative This illustration represents a chemical reaction involving an indole derivative. 1. **Reactants:** - **First molecule (left side):** - The structure contains a benzene ring fused to a five-membered ring with a double bond and an OH (hydroxyl) group attached. - **Second molecule (middle):** - Comprises an amide group (NH₂) with a carbonyl group (C=O) attached. 2. **Reaction:** - These molecules react together, as indicated by the "+" and the arrow, to form a new product. 3. **Product:** - **Final molecule (right side):** - The benzene ring is still fused to the five-membered ring. - A NH₂ (amine) group replaces the initial OH group. This reaction shows the transformation of a hydroxyl group to an amine group within an indole framework, showcasing a common type of organic synthesis used in pharmaceutical chemistry and other chemical industries involving indole derivatives.
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