What happens when one hydrogen on cyclohexane is replaced by a larger substituent?

Introductory Chemistry For Today
8th Edition
ISBN:9781285644561
Author:Seager
Publisher:Seager
Chapter12: Unsaturated Hydrocarbons
Section: Chapter Questions
Problem 12.45E
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What happens when one hydrogen on cyclohexane is replaced by a larger substituent?

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Because axial bonds are parallel to each other, substituents larger than hydrogen generally suffer greater steric crowding when they are oriented axial rather than equatorial. Consequently, substituted cyclohexanes will preferentially adopt conformations in which the larger substituents assume equatorial orientation.

 

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