What are HOX genes' role in lobe-finned fish to limbed tetrapod evolutionary transition?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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What are HOX genes' role in lobe-finned fish to limbed tetrapod evolutionary transition? 

-Please explain "how" HOX genes have influenced these limbs/appendages from an evolutionary standpoint. Thank you.

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HOX genes are known as the highly conserved transcription factors which are a part of the homeobox genes of the living organisms.

Step 2

HOX genes are specific gene transcription factors that regulate and manipulate specific growth factors in living organisms which are responsible for functional and physiological development of higher order living beings. HOX genes are highly conserved across domains in species and helps in the correct position placement of anatomical structures of various organisms, which includes the limbic system as well. Appendages or limbs have evolved from classes and orders of organisms across the taxonomic tree with the due course of time.

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