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Use the following information to answer the next five questions. During the summer of 2013 it was determined that a small Nigerian village had a population of 2,089 people. The per capita incidence of people born with sickle- cell anemia (an autosomal recessive disease) in this village, was the highest in the country with 324 people in this population having the condition. The people with sickle-cell anemia require extensive therapy for this otherwise lethal disease. However, a heterozygous advantage exists with carriers of the sickle-cell allele providing resistance to malaria, a lethal disease that is highly prevalent in this village. People heterozygous for the sickle cell allele produce an environment in some of their blood cells that is toxic to the parasite that causes malaria. Show ALL calculations 1. Calculate the phenotypic frequency of sickle- cell anemia in this population expressed as a number between 0 and 1 and rounded to 2 decimal places 2. Calculate the frequency of the recessive allele in this population expressed as a number between 0 and 1 and rounded to 2 decimal places. 3. Calculate the frequency of the dominant allele in this population expressed as a number between 0 and 1 and rounded to 2 decimal places. 4. How many people (to the nearest whole person) are expected to be resistant to malaria but NOT have full sickle cell anemia 5. Of all the people who do NOT suffer from sickle- cell anemia, how many (to the nearest whole person) are expected to be genotypically homozygous?

Use the following information to answer the next five questions. During the summer of 2013 it was determined that a small Nigerian village had a population of 2,089 people. The per capita incidence of people born with sickle- cell anemia (an autosomal recessive disease) in this village, was the highest in the country with 324 people in this population having the condition. The people with sickle-cell anemia require extensive therapy for this otherwise lethal disease. However, a heterozygous advantage exists with carriers of the sickle-cell allele providing resistance to malaria, a lethal disease that is highly prevalent in this village. People heterozygous for the sickle cell allele produce an environment in some of their blood cells that is toxic to the parasite that causes malaria. Show ALL calculations 1. Calculate the phenotypic frequency of sickle- cell anemia in this population expressed as a number between 0 and 1 and rounded to 2 decimal places 2. Calculate the frequency of the recessive allele in this population expressed as a number between 0 and 1 and rounded to 2 decimal places. 3. Calculate the frequency of the dominant allele in this population expressed as a number between 0 and 1 and rounded to 2 decimal places. 4. How many people (to the nearest whole person) are expected to be resistant to malaria but NOT have full sickle cell anemia 5. Of all the people who do NOT suffer from sickle- cell anemia, how many (to the nearest whole person) are expected to be genotypically homozygous?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Use the following information to answer the next five questions. During the summer of 2013 it was determined that a small Nigerian village had a population of 2,089 people. The per capita incidence of people born with sickle- cell anemia (an autosomal recessive disease) in this village, was the highest in the country with 324 people in this population having the condition. The people with sickle-cell anemia require extensive therapy for this otherwise lethal disease. However, a heterozygous advantage exists with carriers of the sickle-cell allele providing resistance to malaria, a lethal disease that is highly prevalent in this village. People heterozygous for the sickle cell allele produce an environment in some of their blood cells that is toxic to the parasite that causes malaria. Show ALL calculations 1. Calculate the phenotypic frequency of sickle- cell anemia in this population expressed as a number between 0 and 1 and rounded to 2 decimal places 2. Calculate the frequency of the recessive allele in this population expressed as a number between 0 and 1 and rounded to 2 decimal places. 3. Calculate the frequency of the dominant allele in this population expressed as a number between 0 and 1 and rounded to 2 decimal places. 4. How many people (to the nearest whole person) are expected to be resistant to malaria but NOT have full sickle cell anemiat 5. Of all the people who do NOT suffer from sickle- cell anemia, how many (to the nearest whole person) are expected to be genotypically homozygous?
Transcribed Image Text:Use the following information to answer the next five questions. During the summer of 2013 it was determined that a small Nigerian village had a population of 2,089 people. The per capita incidence of people born with sickle- cell anemia (an autosomal recessive disease) in this village, was the highest in the country with 324 people in this population having the condition. The people with sickle-cell anemia require extensive therapy for this otherwise lethal disease. However, a heterozygous advantage exists with carriers of the sickle-cell allele providing resistance to malaria, a lethal disease that is highly prevalent in this village. People heterozygous for the sickle cell allele produce an environment in some of their blood cells that is toxic to the parasite that causes malaria. Show ALL calculations 1. Calculate the phenotypic frequency of sickle- cell anemia in this population expressed as a number between 0 and 1 and rounded to 2 decimal places 2. Calculate the frequency of the recessive allele in this population expressed as a number between 0 and 1 and rounded to 2 decimal places. 3. Calculate the frequency of the dominant allele in this population expressed as a number between 0 and 1 and rounded to 2 decimal places. 4. How many people (to the nearest whole person) are expected to be resistant to malaria but NOT have full sickle cell anemiat 5. Of all the people who do NOT suffer from sickle- cell anemia, how many (to the nearest whole person) are expected to be genotypically homozygous?
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