Uncouplers of oxidative phosphorylation are all expect: Select one: O a. thermogenin O b. dinitrocresol O c. antimycin A O d. 2,4 dinitrophenol
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- A hydrophilic drug A.Has a high reabsorption in renal tubules B.Has a low ability to penetraye the cell membrane C.Can cross the blood brain barrier easily D.Can bind to intracellular receptors. 2.The phase 1 reaction most often performed by mixed function CYP450 hepatic microsomal enzyme is A.Glucuronidation B.Oxidation C.Reduction D.Acetylation 3.CYP1A2 is involved in the metabolizing of several clinically important xenobiotics such as A.Caffeine B.Morphine C.Aspirin D.Alcohol 4.Drug metabolism,the drug.......undergoes phase 2(acetylation)before undergoing phase 1 (hydrolysis) metabolic reactions A Aspirin B.Codeine C.Isoniazid D.Diazepam E.Phenytoin 5.Which of the following statements is/are true regarding the oxidation of aromatic rings A.Electron donating substituents promote oxidationat the meta position B.Electron withdrawing substituents promote oxidation at the meta position C.All aromatic rings in a molecule are hydroxylated D Monosubstituted aromatic rings can be…which of the following are possible sources of glyceraldehyde 3-phosphate a. more than 1 correct response b. 2 moles of glucos c. cleavage of fructose-1-6-biphosphate d. dihydroxyacetone phosphateThe following enzymes belong to the same class of enzymes, except for A. Chymotrypsin B. Thrombin C. Lysozyme D. Alcohol dehydrogenase E. Elastase
- Which of the following molecules are not involved in lipolysis within adipocytes? a. protein kinase A b. PEPCK c. adenylate cyclase d. perilipin-1Define the following terms: a. thiolytic cleavage b. ketogenesis c. ketone bodies d. α-oxidation e. ACCWhich of the following is not formed during the TCA cycle a. Isocitrate b. Both Lactate and Isocitrate c. Lactate d. Succinate
- Which of the following are clinical manifestations of oxidative phosphorylation disorders ? (more than one answer) a. cardiomyopathy b. ophthalmoplegia c. seizures d. muscle weaknessDefine the following terms: a. sdLDL b. oxLDL c. cytochrome P450 d. atheroma e. abetalipoproteinemiaUpon the addition of diazonium salts, ketoacids like glutamate and pyruvate forms in the presence of hydroxide as a color developer in Reitman Frankel Method. At pH 6.8, Pyruvate kinase catalyzes the transfer of phosphate from phosphoenolpyruvate to ADP to become ATP a. both false b. both are true c.. only second is true d. only first is true 2. constriction of the sphincter of oddi may cause falsely ______ in ____ activity a. none of the choices b. decresed, lipase c. increased, ck-mb d. increaased, amylase e. decreased, LDH 3. The amyloclastic method of amylase activity determination refers to the measurement of the disappearance of the starch substrate when mixed with amylase in the sample. The addition of L-tartrate measurement of CP activity increases the sensitivuty of the substrate used to the prostatic ACP isoenzyme a. both are true b. both are false c. only second is true d. only first is true
- 17. Accumulation of high levels of chloramphenicol in newbom that leads to a gray baby syndrome is due to он H .CHCI2 O,N- но chloramphenicol A. Lack of UDP-glucuronosyltransferase B. Renal uptake of metabolized product C. High lipophilicity of chloramphenicol D. Poor absorption of chloramphenicol 16Please answer the following: 1. Glycogen stored in muscle and liver is used for following organs in the order: Select one: a.blood, muscle b. synthesis of glycogen of muscle c. only for muscle exercise d. muscle, brain 2. Glycogen phosphorylase a (enzyme) becomes active once Select one: a. phosphorylase kinase lacks phosphorlyation b. phosphorylase kinase lacks Ca cofactor c. phosphorylase kinase is active d. Gucose is present 3. What is the necessary coenzyme for transamination reactions? Select one: a. Coenzyme A b. Thiamine pyrophosphate c. NAD d. Pyridoxal phosphate 4. Amino Acids Are Activated by _ , and attached to Transfer RNA Select one: a. ATP b. UTP c. GTP d. CTP 5. Which of the following is incorrect statement about introns? Select one: a. Integral to gene expression regulation b. They are protein coding genes c. They are non-protein coding genes d. They are removed by splicingWhich of the given metabolites is common in respiration mediated breakdown of fat and protein? a.Dihydroxyacetone phosphate b.Glyceraldehyde 3 phosphate c.Acetyl CoA d.Phosphoenol pyruvate