Triosephosphate isomerase (TIM) catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate. The enzyme's catalytic groups are Glu 165 and His 95. In the first step of the reaction, these catalytic groups function as a base and an acid catalyst, respectively. Propose a mechanism for the reaction. 2-O,POOH dihydroxyacetone phosphate I OH triosephosphate isomerase 2-03PO H FYI Glu is glutamic acid and his is histadine glyceraldehyde-3-phosphate
Triosephosphate isomerase (TIM) catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate. The enzyme's catalytic groups are Glu 165 and His 95. In the first step of the reaction, these catalytic groups function as a base and an acid catalyst, respectively. Propose a mechanism for the reaction. 2-O,POOH dihydroxyacetone phosphate I OH triosephosphate isomerase 2-03PO H FYI Glu is glutamic acid and his is histadine glyceraldehyde-3-phosphate
Chapter29: The Organic Chemistry Of Metabolic Pathways
Section29.SE: Something Extra
Problem 23MP: One of the steps in the pentose phosphate pathway for glucose catabolism is the reaction of...
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Please draw by hand. Triosephosphate isomerase (TIM) catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate. The enzyme's catalytic groups are Glu 165 and His 95. In the first step of the reaction, these catalytic groups function as a base and an acid catalyst, respectively. Propose a mechanism for the reaction.
ОН
2-03Р0
ОН
dihydroxyacetone phosphate
triosephosphate isomerase
2-03РО.
H
glyceraldehyde-3-phosphate
FYI Glu is glutamic acid and his is histadine
Transcribed Image Text:Triosephosphate isomerase (TIM) catalyzes the conversion of dihydroxyacetone
phosphate to glyceraldehyde-3-phosphate. The enzyme's catalytic groups are Glu 165 and
His 95. In the first step of the reaction, these catalytic groups function as a base and an
acid catalyst, respectively. Propose a mechanism for the reaction.
2-O,POOH
dihydroxyacetone phosphate
I
OH
triosephosphate isomerase
2-03PO
H
FYI Glu is glutamic acid and his is histadine
glyceraldehyde-3-phosphate
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