Trait: Neurofibromatosis The dominant form is neurofibromatosis, caused by the production of an abnormal form of the protein neurofibromin. Affected individuals show spots of abnormal skin pigmentation and non-cancerous tumors that can interfere with the nervous system and cause blindness. Some tumors can convert to a cancerous form. The recessive form is a normal protein - in other words, no neurofibromatosis. Situation: Karina wants to know from whom she got her disorder. Her grandmother Ana has neurofibromatosis. Ana marries Angelo, who does not have the disease. They both have children named Christine (eldest), Monica, Joseph, Marco, and Yna (youngest). Monica, Marco, and Yna have the disorder out of the five children. Christine marries a man with the disorder, and they have two daughters, Kadita and Karina, who both have the disorder, and another daughter, Karrie, who does not have neurofibromatosis. Yna, on the other hand, marries a man with the disorder. They have four children, Dianne, Danica, Dennis, and Dan. Danica and Dennis have the disorder. Show the computations in the following: 1. What is the chance of having that trait if II-6 marries a man who does not have that trait? 2. What is the chance of having that trait if II-2, marries a man who is heterozygous for the trait? 3. Make a Punnet square that shows the cross of the traits of the grandparents, then give the phenotypic and genotypic ratios.
Trait: Neurofibromatosis
The dominant form is neurofibromatosis, caused by the production of an abnormal form of the protein neurofibromin. Affected individuals show spots of abnormal skin pigmentation and non-cancerous tumors that can interfere with the nervous system and cause blindness. Some tumors can convert to a cancerous form.
The recessive form is a normal protein - in other words, no neurofibromatosis.
Situation:
Karina wants to know from whom she got her disorder. Her grandmother Ana has neurofibromatosis. Ana marries Angelo, who does not have the disease. They both have children named Christine (eldest), Monica, Joseph, Marco, and Yna (youngest). Monica, Marco, and Yna have the disorder out of the five children. Christine marries a man with the disorder, and they have two daughters, Kadita and Karina, who both have the disorder, and another daughter, Karrie, who does not have neurofibromatosis. Yna, on the other hand, marries a man with the disorder. They have four children, Dianne, Danica, Dennis, and Dan. Danica and Dennis have the disorder.
Show the computations in the following:
1. What is the chance of having that trait if II-6 marries a man who does not have that trait?
2. What is the chance of having that trait if II-2, marries a man who is heterozygous for the trait?
3. Make a Punnet square that shows the cross of the traits of the grandparents, then give the
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