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Ticlopidine is an antiplatelet drug used to prevent strokes. Draw an alkyl halide and choose the conditions that would promote an SN2 reactions yield this intermediate in the synthesis of ticlopidine. Draw Starting Alkyl Halide

Ticlopidine is an antiplatelet drug used to prevent strokes. Draw an alkyl halide and choose the conditions that would promote an SN2 reactions yield this intermediate in the synthesis of ticlopidine. Draw Starting Alkyl Halide

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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**Chemical Reaction: Ring Expansion and Substitution** In this image, a chemical reaction is depicted involving the transformation of one compound into another using a specific reagent. **Starting Material**: - The initial compound features a thiochromene ring structure. It contains a sulfur atom (S) and a secondary amine group (NH). **Reaction Conditions**: - The reaction is carried out in the presence of Potassium carbonate (K₂CO₃) and ethanol. **Product**: - The product of the reaction shows a newly formed heterocyclic compound where the original ring structure has expanded. - The expanded structure includes an additional aromatic ring with a chlorine substituent (Cl) attached. **Explanation of Reaction Process**: - The reaction likely involves a nucleophilic substitution or a ring expansion process, facilitated by the basic K₂CO₃ in an ethanol solvent, leading to the incorporation of the chloro-functionalized aromatic ring into the original structure. This reaction is an example of how ring structure complexities are enhanced through chemical transformations, reflective of processes used in organic synthesis and pharmaceutical development.
Transcribed Image Text:**Chemical Reaction: Ring Expansion and Substitution** In this image, a chemical reaction is depicted involving the transformation of one compound into another using a specific reagent. **Starting Material**: - The initial compound features a thiochromene ring structure. It contains a sulfur atom (S) and a secondary amine group (NH). **Reaction Conditions**: - The reaction is carried out in the presence of Potassium carbonate (K₂CO₃) and ethanol. **Product**: - The product of the reaction shows a newly formed heterocyclic compound where the original ring structure has expanded. - The expanded structure includes an additional aromatic ring with a chlorine substituent (Cl) attached. **Explanation of Reaction Process**: - The reaction likely involves a nucleophilic substitution or a ring expansion process, facilitated by the basic K₂CO₃ in an ethanol solvent, leading to the incorporation of the chloro-functionalized aromatic ring into the original structure. This reaction is an example of how ring structure complexities are enhanced through chemical transformations, reflective of processes used in organic synthesis and pharmaceutical development.
**Title: Understanding the Synthesis of Ticlopidine** **Introduction:** Ticlopidine is an antiplatelet drug used to prevent strokes. In this exercise, you will learn how to synthesize an intermediate required in the production of ticlopidine by performing an SN2 reaction. **Instructions:** 1. **Draw an Alkyl Halide:** - Start by drawing a suitable alkyl halide. This compound will undergo an SN2 reaction. 2. **Reactants and Reaction Conditions:** - Combine the alkyl halide with the indicated bicyclic compound containing sulfur (S) and nitrogen-hydrogen (NH) groups. - Use potassium carbonate (K₂CO₃) as the base in ethanol as the solvent, facilitating the SN2 reaction. **Diagram Explanation:** - **Chemical Structure:** The image shows a bicyclic compound structure that will react with your chosen alkyl halide. - **SN2 Reaction Pathway:** The reaction arrow indicates the direction of the nucleophilic substitution, leading to the formation of the desired intermediate. **Objective:** Select the correct alkyl halide and understand the mechanism that supports the SN2 process to successfully synthesize the intermediate used in ticlopidine production. This exercise reinforces knowledge of reaction mechanisms and organic synthesis pathways.
Transcribed Image Text:**Title: Understanding the Synthesis of Ticlopidine** **Introduction:** Ticlopidine is an antiplatelet drug used to prevent strokes. In this exercise, you will learn how to synthesize an intermediate required in the production of ticlopidine by performing an SN2 reaction. **Instructions:** 1. **Draw an Alkyl Halide:** - Start by drawing a suitable alkyl halide. This compound will undergo an SN2 reaction. 2. **Reactants and Reaction Conditions:** - Combine the alkyl halide with the indicated bicyclic compound containing sulfur (S) and nitrogen-hydrogen (NH) groups. - Use potassium carbonate (K₂CO₃) as the base in ethanol as the solvent, facilitating the SN2 reaction. **Diagram Explanation:** - **Chemical Structure:** The image shows a bicyclic compound structure that will react with your chosen alkyl halide. - **SN2 Reaction Pathway:** The reaction arrow indicates the direction of the nucleophilic substitution, leading to the formation of the desired intermediate. **Objective:** Select the correct alkyl halide and understand the mechanism that supports the SN2 process to successfully synthesize the intermediate used in ticlopidine production. This exercise reinforces knowledge of reaction mechanisms and organic synthesis pathways.
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