The structure of a chiral isomer is given. Draw the mirror image isomer. Use wedge-and-dash bonds for the substituent groups, and be sure that the bonds convey tetrahedral geometry. Draw the mirror image. НО. Br CI H **** CI Br < Feedback Draw the skeletal structure, then determine where the substituents should go to produce the other stereoisomer (mirror image). Be sure that the skinny end of both the wedge and dash bonds point to the chirality center.

Click on all structures that are enantiomers of the first (leftmost). If no structure qualifies, submit your answer without selecting any structure. OCH 3 H₂CO H CH=CH₂ HI F CH=CH₂ Fill H CH=CH₂ OCH3 H₂C=CHI OCH3 H

Use flat representation of rings, not chair in the drawing. Determine the most and least stable.    Consider the most stable chair for each of these isomers, and then draw the most stable and least stable isomer based on a comparison of the best chair for each one.

Please type out your answer, cannot be hand-drawn

Draw a structural formula of the R configuration of the compound shown below.

4. For each of the following molecules, label each stereocenter as R or S. Label the molecules appropriately as chiral or meso. a. b. methionine NH₂ H d. но. OH c. D = 2H, T = ³H, isotopes of hydrogen. f.T. OH OH CI Y ОН

Name: Expt. 4: Molecular Models: Stereoisomers Laboratory Work – Be sure and answer all questions embedded in the text. Shown below is a representation of 2-bromopropane. a. Draw the mirror image of this representation. b. Build a model of each structure. Are the two structures superimposable? 1. 1o fro c. Look carefully at one of your models. Do you see a mirror plane of symmetry in the molecule? d. If so, draw where it is or describe in words what the plane is. er an steren somers H. CH3 . -Br CH3 mirror plane

Highlight each chiral center in the following molecule. If there are none, then check the box under the drawing area. HO There are no chiral centers. CI X 3

ITEM #5 (Everyone should look at this question). Consider the two Fischer projections shown at right. They CH CH are NOT of the same molecule. H- -HO- HO In a short paragraph, explain why the molecules shown are NOT the same. OH но- H. HO. но In your explanation, describe how the groups of a Fischer projection are positioned in the ACTUAL molecule (Are the molecules flat in real life, or three-dimensional in real life? If three-dimensional, where exactly are the Hs and OHs positioned when one interprets these projections?) H- HO но H- CH,OH ČH;OH Also in your explanation, describe why the second molecule is not simply the first molecule flipped over (like a pancake).

Atomic #'s & Masses: Carbon: 6, 12.01g/mole Oxygen: 8, 16.00g/mole H: 1, 1.01g/mole 4. Answer questions for the following molecule: a. Circle any/all chiral centers. b. Is the molecule chiral or achiral. H H CH₂ CH₂ Br Br