the stomach, why is omeprazole not orally administered directly to the stomach?

Chemistry for Today: General, Organic, and Biochemistry
9th Edition
ISBN:9781305960060
Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Publisher:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Chapter18: Lipids
Section: Chapter Questions
Problem 18.79E: Accumulation of cholesterol leads to the hardening of the arteries. This is called:...
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Omeprazole is administered
orally as a galenic formulation to
protect it from being activated
during its journey through the
acidic contents of the stomach.
Once it is released in the
intestines, it is absorbed into the
blood supply and carried to the
parietal cells where it crosses the
cell membrane into the canaliculi
and is activated. As the canaliculi
lead directly into the lumen of
the stomach, why is omeprazole
not orally administered directly
to the stomach?
Transcribed Image Text:Omeprazole is administered orally as a galenic formulation to protect it from being activated during its journey through the acidic contents of the stomach. Once it is released in the intestines, it is absorbed into the blood supply and carried to the parietal cells where it crosses the cell membrane into the canaliculi and is activated. As the canaliculi lead directly into the lumen of the stomach, why is omeprazole not orally administered directly to the stomach?
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