The purine nucleotide cycle produces fumarate, _____________, and _____________.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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The purine
Expert Solution
Step 1
Purine nucleotide cycle is a 3 step reversible process. This cycle checks the level of ATP in the body and maintains it so that body does not runs out of it.
Step 2
Purine nucleotide cycle generates ammonia and fumarate from aspartate and inosine monophosphate (IMP). This is done to regulate the level of ATP in our body via regulating the adenosine nucleotide level.
Three steps are involved in the overall process-
- Hydrolysis of AMP to produce ammonia and IMP
- Aspartate in the presence of IMP and GTP produces adenylosuccinate
- Adenylosuccinate is cleaved to form fumarate and AMP by an enzyme adenylosuccinate lyase.
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