The Principle of Microscopic Reversibility states that a forward reaction and a reversereaction taking place under the same conditions (as in an equilibrium) must follow thesame reaction pathway in microscopic detail. The reverse of the Fischer esterificationis the acid-catalyzed hydrolysis of an ester. Propose a mechanism for the acid-catalyzedhydrolysis of ethyl benzoate, PhCOOCH2CH3
Catalysis and Enzymatic Reactions
Catalysis is the kind of chemical reaction in which the rate (speed) of a reaction is enhanced by the catalyst which is not consumed during the process of reaction and afterward it is removed when the catalyst is not used to make up the impurity in the product. The enzymatic reaction is the reaction that is catalyzed via enzymes.
Lock And Key Model
The lock-and-key model is used to describe the catalytic enzyme activity, based on the interaction between enzyme and substrate. This model considers the lock as an enzyme and the key as a substrate to explain this model. The concept of how a unique distinct key only can have the access to open a particular lock resembles how the specific substrate can only fit into the particular active site of the enzyme. This is significant in understanding the intermolecular interaction between proteins and plays a vital role in drug interaction.
The Principle of Microscopic Reversibility states that a forward reaction and a reverse
reaction taking place under the same conditions (as in an equilibrium) must follow the
same reaction pathway in microscopic detail. The reverse of the Fischer esterification
is the acid-catalyzed hydrolysis of an ester. Propose a mechanism for the acid-catalyzed
hydrolysis of ethyl benzoate, PhCOOCH2CH3
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