Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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- F. Written Response 1. If gene transcription is inhibited after fertilization, development past the two-cell stage does not take place in the mouse. However, in frog embryos, this treatment does not disrupt development until late cleavage. Explain this difference. 2. Twist transcription factors (TF) play key roles in embryonic development and are largely undetectable in normal adult tissues; however, their expression is reactivated during tumor progression and correlates with invasive and metastatic lesions. Transcription of the Twist gene is activated by Wnt signals and the Twist TF represses the gene for E-cadherin. Answer the following questions as briefly as possible, based on what was presented in class, not an internet search (complex answers that go beyond class material may lose points) a. Outline the steps from the Wnt signal to the E-cadherin gene (inclusive); e.g., A → B → C (with some clarifications such as "binds to", "activates", "represses") b. What are the normal…arrow_forward4. How do embryonic and adult stem cells differ?arrow_forward2. The first human cells to be successfully cultured were derived from a malignant tumor. Do you think this simply reflects the availability of cancer cells, or might such cells be better subjects for cell culture? Why?arrow_forward
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