The polycistronic Histidine Operon in E. coli encodes all of the proteins necessary for the biosynthesis of the amino acid histidine. His X is a separate operon that encodes the His X protein. His X regulates the His Operon by positive regulation. The fact that His X engages in positive regulation means that His X promotes RNA pol binding to the His Operon promoter His X might promote or inhibit RNA pol binding to the His Operon promoter depending on how histidine affects His X DNA binding ability E. coli transcribes the His Operon only when histidine levels are high E. coli transcribes the His Operon only when histidine levels are low His X blocks RNA pol binding to the His Operon promoter

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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The polycistronic Histidine Operon in E. coli encodes all of the proteins
necessary for the biosynthesis of the amino acid histidine. His X is a separate
operon that encodes the His X protein. His X regulates the His Operon by
positive regulation. The fact that His X engages in positive regulation means
that
O His X promotes RNA pol binding to the His Operon promoter
His X might promote or inhibit RNA pol binding to the His Operon promoter
depending on how histidine affects His X DNA binding ability
E. coli transcribes the His Operon only when histidine levels are high
O E. coli transcribes the His Operon only when histidine levels are low
His X blocks RNA pol binding to the His Operon promoter
Transcribed Image Text:The polycistronic Histidine Operon in E. coli encodes all of the proteins necessary for the biosynthesis of the amino acid histidine. His X is a separate operon that encodes the His X protein. His X regulates the His Operon by positive regulation. The fact that His X engages in positive regulation means that O His X promotes RNA pol binding to the His Operon promoter His X might promote or inhibit RNA pol binding to the His Operon promoter depending on how histidine affects His X DNA binding ability E. coli transcribes the His Operon only when histidine levels are high O E. coli transcribes the His Operon only when histidine levels are low His X blocks RNA pol binding to the His Operon promoter
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