"The mechanism does not recruit a homologous region of DNA during repair". Explain this ?

Certain DNA sequences are especially prone to “strand slippage.” In your own words, give an account of how this phenomenon can lead to a specific genetic disease.

Proteins don't have the same extent of repair mechanisms that nucleic acids do. Therefore, when they get damaged, they often need to be broken down. Describe how this process occurs - how are "bad" proteins identified, what happens to them, and how are they degraded?

Faulty DNA repair; ii) Gain-of-function; and iii) Trinucleotide repeats  provide genetics disorders Give examples of mutations with each disorder.

Consider a DNA molecule with the following structure a. if during replication , the T at position 4 is read as an A resulting in a misincorporation in the new DNA strand . If the misincorporation is not repair , draw or write the results of the second round of replication b. After the second round of replication , what specific type of point mutation is now permanent in the DNA sequence ? c. List the two cellular mechanisms that failed to prevent the establishment of this permanent mutation .

Explain why DNA replication is slightly slower in the lagging strand of DNA than in the leading strand.

DNA polymerase occasionally incorporates the wrong nucleotide during DNA replication. If left unrepaired, the base-pair mismatch that results will lead to mutation in the next replication. As part of a template strand, the incorporated wrong base will direct the incorporation of a base complementary to itself, so the bases on both strands of the DNA at that position will now be different from what they were before the mismatch event. The MER-minus strain of yeast does not have a functional  mismatch excision repair system, but it has normal base excision repair and nucleotide excision repair systems. Which of the following statements is correct about differences in the mutation spectrum between MER-minus and wildtype yeast? More than one answer is correct. Options:   More point mutations will arise in MER-minus yeast.   Fewer point mutations will arise in MER-minus yeast as compared with wildtype.   Of the total point mutations that…

"DNA repair mechanism all depend on the existence of two copies of the genetic information, one in each of the two homologous chromosomes" is true or false.

If the following nucleotide sequence, CTC/TGT/AAG/ACC/TTT experienced a mutation resulting in the deletion of the second cytosine in the first DNA triplet so the sequence is now CT_/TGT/AAG/ACC/TTT, what would be the amino acid sequence created from this mutated DNA strand? Table of mRNA codons UUA, UUG = leucine AGG, AGA = arginine %3D CAU, CAC = histidine GUU, GÜC, GUA = valine GAA. GAG=glutamic acid GCU, GUA, GUG = alanine GAU, GAC = asparagine GGU, GGC, GGA = glycine UCA, UCU =serine CGU, CGC, CGA = arginine

Is DNA fragmentation genetic?