The MC1R gene affects skin and hair color in humans.There are at least 13 polymorphisms of the gene inEuropean and Asian populations, 10 of which are nonsynonymous. In Africans, there are at least 5 polymorphisms of the gene, none of which are nonsynonymous.What might be one explanation for the differences inMC1R variation between Africans and non-Africans?

The MC1R gene affects skin and hair color in humans.There are at least 13 polymorphisms of the gene inEuropean and Asian populations, 10 of which are nonsynonymous. In Africans, there are at least 5 polymorphisms of the gene, none of which are nonsynonymous.What might be one explanation for the differences inMC1R variation between Africans and non-Africans?

Name: The MC1R gene affects skin and hair color in humans.There are at least
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Description: The MC1R gene affects skin and hair color in humans.There are at least 13 polymorphisms of the gene inEuropean and Asian populations, 10 of which are nonsynonymous. In Africans, there are at least 5 polymorphisms of the gene, none of which are nonsyn

Biology (MindTap Course List)

11th Edition

ISBN:9781337392938

Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Chapter16: Human Genetics And The Human Genome

Section16.6: Human Genetics, Society, And Ethics

Problem 1C

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In a study of a muscle disorder, several affected families exhibited vision problems, muscle weakness, and deafness (M. Zeviani et al. 1990. American Journal of Human Genetics 47:904–914). Analysis of the mtDNA from affected members of these families revealed that large numbers of their mtDNA molecules possessed deletions of varying lengths. Different members of the same family and even different mitochondria from the same person possessed deletions of different sizes, so the underlying defect appeared to be a tendency for the mtDNA of affected persons to have deletions. A pedigree of one of the families studied is shown below. The researchers concluded that this disorder is inherited as an autosomal dominant trait, and they mapped the diseasecausing gene to a position on chromosome 10 in the nucleus. Q. Explain how a mutation in a nuclear gene might lead to deletions in mtDNA.
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